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1. (WO2014152211) FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/152211 International Application No.: PCT/US2014/027077
Publication Date: 25.09.2014 International Filing Date: 14.03.2014
IPC:
C12N 15/87 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Applicants:
MODERNA THERAPEUTICS, INC. [US/US]; 320 Bent Street Cambridge, Massachusetts 02141, US
Inventors:
HOGE, Stephen G.; US
ALMARSSON, Örn; US
HILE, David D.; US
LAWLOR, Ciarán; US
PODOBINSKI, John; US
SABNIS, Staci; US
DE FOUGEROLLES, Antonin; BE
RAMAKRISHNAN, Divakar; US
WOOD, Kristy M.; US
Agent:
WARD, Donna T.; 142A Main Street Groton, Massachusetts 01450, US
Priority Data:
61/782,71614.03.2013US
61/821,40609.05.2013US
61/840,51028.06.2013US
61/877,48513.09.2013US
61/942,89421.02.2014US
Title (EN) FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
(FR) FORMULATION ET ADMINISTRATION DE COMPOSITIONS DE NUCLÉOSIDES, DE NUCLÉOTIDES, ET D'ACIDES NUCLÉIQUES MODIFIÉS
Abstract:
(EN) The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
(FR) La présente invention concerne, entre autres, des compositions de formulation comportant des molécules d'acides nucléiques modifiés pouvant coder pour une protéine, un précurseur de protéines, ou une forme partiellement ou entièrement transformée de la protéine ou d'un précurseur de protéine. La composition de la formulation peut également comporter une molécule d'acide nucléique modifié et un agent d'administration. La présente invention concerne également des acides nucléiques utiles pour coder pour des polypeptides capables de moduler la fonction et/ou l'activité d'une cellule.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)