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1. WO2014150639 - PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES

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Publication Number WO/2014/150639
Publication Date 25.09.2014
International Application No. PCT/US2014/023858
International Filing Date 12.03.2014
IPC
A61K 31/40 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
CPC
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 215/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
22the carbon skeleton being unsaturated
28and containing six-membered aromatic rings
30containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
C07D 207/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
C07D 207/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12Oxygen or sulfur atoms
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • XU, Feng [US]/[US] (US)
  • LIU, Zhuqing [CN]/[US] (US)
  • DESMOND, Richard [US]/[US] (US)
  • PARK, Jeonghan [US]/[US] (US)
  • KALININ, Alexei [CA]/[US] (US)
  • KOSJEK, Birgit [AT]/[US] (US)
  • STROTMAN, Hallena [US]/[US] (US)
  • LI, Hongmei [CN]/[US] (US)
  • MONCECCHI, Johannah [US]/[US] (US)
Inventors
  • XU, Feng
  • LIU, Zhuqing
  • DESMOND, Richard
  • PARK, Jeonghan
  • KALININ, Alexei
  • KOSJEK, Birgit
  • STROTMAN, Hallena
  • LI, Hongmei
  • MONCECCHI, Johannah
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
61/791,24715.03.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES
(FR) PROCÉDÉ DE PRÉPARATION D'AGONISTES BÊTA-3 ET D'INTERMÉDIAIRES
front page image
Abstract
(EN) The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
(FR) L'invention concerne des procédés efficaces et économiques tels que décrits plus en détail ci-dessous pour la préparation des agonistes bêta-3 de la formule I-7 et des composés intermédiaires qui peuvent être utilisés pour fabriquer ces agonistes. La présente invention concerne un procédé pour fabriquer des agonistes bêta-3 et des intermédiaires à l'aide d'enzymes biocatalyseurs de cétoréductase (KRED) et les procédés d'utilisation des biocatalyseurs.
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