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1. (WO2014150639) PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/150639 International Application No.: PCT/US2014/023858
Publication Date: 25.09.2014 International Filing Date: 12.03.2014
IPC:
A61K 31/40 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Applicants:
MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
XU, Feng [US/US]; US (US)
LIU, Zhuqing [CN/US]; US (US)
DESMOND, Richard [US/US]; US (US)
PARK, Jeonghan [US/US]; US (US)
KALININ, Alexei [CA/US]; US (US)
KOSJEK, Birgit [AT/US]; US (US)
STROTMAN, Hallena [US/US]; US (US)
LI, Hongmei [CN/US]; US (US)
MONCECCHI, Johannah [US/US]; US (US)
Inventors:
XU, Feng; US
LIU, Zhuqing; US
DESMOND, Richard; US
PARK, Jeonghan; US
KALININ, Alexei; US
KOSJEK, Birgit; US
STROTMAN, Hallena; US
LI, Hongmei; US
MONCECCHI, Johannah; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
61/791,24715.03.2013US
Title (EN) PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES
(FR) PROCÉDÉ DE PRÉPARATION D'AGONISTES BÊTA-3 ET D'INTERMÉDIAIRES
Abstract:
(EN) The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
(FR) L'invention concerne des procédés efficaces et économiques tels que décrits plus en détail ci-dessous pour la préparation des agonistes bêta-3 de la formule I-7 et des composés intermédiaires qui peuvent être utilisés pour fabriquer ces agonistes. La présente invention concerne un procédé pour fabriquer des agonistes bêta-3 et des intermédiaires à l'aide d'enzymes biocatalyseurs de cétoréductase (KRED) et les procédés d'utilisation des biocatalyseurs.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2968269US20170145014