WO2014149073 METHODS OF MANUFACTURE AND SYNTHESIS OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR TARGETED IMAGING OF TUMORS

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Publication Number WO/2014/149073

Publication Date 25.09.2014

International Application No. PCT/US2013/063593

International Filing Date 04.10.2013

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CPC

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Applicants

ON TARGET LABORATORIES LLC [US]/[US]

Inventors

KULARATNE, Sumith, A.
GAGARE, Pravin
NOSHI, Mohammad

Agents

D'HUE, Cedric, A.

Priority Data

61/791,921		15.03.2013		US
PCT/US2013/056629		26.08.2013		US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) METHODS OF MANUFACTURE AND SYNTHESIS OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR TARGETED IMAGING OF TUMORS

(FR) PROCÉDÉS DE FABRICATION ET DE SYNTHÈSE DE GROUPES DE LIAISON D'ACIDE AMINÉ CONJUGUÉS À DES COMPOSÉS UTILISÉS POUR L'IMAGERIE CIBLÉE DE TUMEURS

Abstract

(EN) Methods of synthesis and compositions of use for compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyi ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof.

(FR) L'invention concerne des procédés de synthèse et des compositions destinées à l'utilisation pour des composés qui sont utiles en tant que sondes de fluorescence proche infrarouge, les composés comprenant i) un ligand pteroyi qui se lie à une protéine de récepteur cible, ii) une molécule de colorant et iii) une molécule de liaison qui comprend un acide aminé ou un dérivé de celui-ci.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
001	Preparation for luminescence or biological staining

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
001	Preparation for luminescence or biological staining
0013	Luminescence
0017	Fluorescence in vivo
0019	characterised by the fluorescent group
0021	the fluorescent group being a small organic molecule

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
001	Preparation for luminescence or biological staining
0013	Luminescence
0017	Fluorescence in vivo
0019	characterised by the fluorescent group
0021	the fluorescent group being a small organic molecule
0032	Methine dyes, e.g. cyanine dyes

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1. WO2014149073 - METHODS OF MANUFACTURE AND SYNTHESIS OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR TARGETED IMAGING OF TUMORS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
475	Heterocyclic compounds containing pteridine ring systems
02	with an oxygen atom directly attached in position 4
04	with a nitrogen atom directly attached in position 2

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21	Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62	Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63	optically excited
64	Fluorescence; Phosphorescence
6428	Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
6432	Quenching

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
435	from animals; from humans
705	Assays involving receptors, cell surface antigens or cell surface determinants

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005	involving human or animal cells
5091	for testing the pathological state of an organism

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
566	using specific carrier or receptor proteins as ligand binding reagents ; where possible specific carrier or receptor proteins are classified with their target compounds

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
569	for microorganisms, e.g. protozoa, bacteria, viruses
56966	Animal cells