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1. WO2014149073 - METHODS OF MANUFACTURE AND SYNTHESIS OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR TARGETED IMAGING OF TUMORS

Publication Number WO/2014/149073
Publication Date 25.09.2014
International Application No. PCT/US2013/063593
International Filing Date 04.10.2013
IPC
A61K 49/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
CPC
A61K 49/001
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
A61K 49/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
A61K 49/0032
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0032Methine dyes, e.g. cyanine dyes
A61K 49/0034
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0032Methine dyes, e.g. cyanine dyes
0034Indocyanine green, i.e. ICG, cardiogreen
A61K 49/0052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
005characterised by the carrier molecule carrying the fluorescent agent
0052Small organic molecules
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • ON TARGET LABORATORIES LLC [US]/[US]
Inventors
  • KULARATNE, Sumith, A.
  • GAGARE, Pravin
  • NOSHI, Mohammad
Agents
  • D'HUE, Cedric, A.
Priority Data
61/791,92115.03.2013US
PCT/US2013/05662926.08.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF MANUFACTURE AND SYNTHESIS OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR TARGETED IMAGING OF TUMORS
(FR) PROCÉDÉS DE FABRICATION ET DE SYNTHÈSE DE GROUPES DE LIAISON D'ACIDE AMINÉ CONJUGUÉS À DES COMPOSÉS UTILISÉS POUR L'IMAGERIE CIBLÉE DE TUMEURS
Abstract
(EN) Methods of synthesis and compositions of use for compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyi ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof.
(FR) L'invention concerne des procédés de synthèse et des compositions destinées à l'utilisation pour des composés qui sont utiles en tant que sondes de fluorescence proche infrarouge, les composés comprenant i) un ligand pteroyi qui se lie à une protéine de récepteur cible, ii) une molécule de colorant et iii) une molécule de liaison qui comprend un acide aminé ou un dérivé de celui-ci.
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