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1. (WO2014140930) COMPOSITIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/140930 International Application No.: PCT/IB2014/001248
Publication Date: 18.09.2014 International Filing Date: 13.03.2014
IPC:
A61K 31/437 (2006.01) ,A61K 35/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
LONZA COLOGNE GMBH; Nattermannalle 1 50829 Koln, DE
Inventors:
VAN DEN BOS, Christian; DE
REINISCH, Barbara; DE
SCHENK, Judith; DE
ROSENBAUM, Claudia; DE
Priority Data:
13159548.015.03.2013EP
Title (EN) COMPOSITIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS
(FR) COMPOSITIONS ET PROCÉDÉS POUR AMÉLIORER LE POTENTIEL THÉRAPEUTIQUE DE CELLULES SOUCHES
Abstract:
(EN) The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve- administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin II antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.
(FR) L'invention englobe des compositions et des méthodes de traitement d'une maladie vasculaire, telle qu'une maladie artérielle périphérique, les procédés mettant en jeu l'administration à un patient en ayant besoin d'une quantité efficace d'une composition comprenant une population de cellules, telles que des cellules souches mésenchymateuses (MSC), et un antagoniste non myosine musculaire O tel que la blebbistatine. Les antagonistes de myosine non musculaires II de l'invention, de façon surprenante et dramatique, accélèrent la régénération déclenchée par MSC des tissus endommagés et, de façon inattendue et drastique, réduisent des complications graves de traitement par des cellules souches.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)