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1. (WO2014128198) BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES

Pub. No.:    WO/2014/128198    International Application No.:    PCT/EP2014/053294
Publication Date: Fri Aug 29 01:59:59 CEST 2014 International Filing Date: Fri Feb 21 00:59:59 CET 2014
IPC: C07C 213/02
C07C 217/60
A61K 31/137
A61K 31/14
A61P 31/14
A61P 31/18
A61P 31/04
A61P 35/00
Applicants: CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE
INSTITUTO DE SALUD CARLOS III
UNIVERSIDAD CATÓLICA DE VALENCIA "SAN VICENTE MÁRTIR"
UNIVERSITAT DE VALÈNCIA
Inventors: GALLEGO SALA, José
FUSTERO LARDIÉS, Santos
ALCAMÍ PERTEJO, José
GONZÁLEZ BULNES, Luis
IBAÑEZ SÁNCHEZ, Ignacio
CATALÁN MUÑOZ, Silvia
PRADO MARTÍN, Silvia
CANTERO CAMACHO, Ángel
BARRIO FERNÁNDEZ, Pablo
Title: BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES
Abstract:
The invention relates to bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein a-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of a-helical proteins in interaction with other biomolecules.