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1. WO2014124425 - GENERATION OF FUNCTIONAL DENDRITIC CELLS

Publication Number WO/2014/124425
Publication Date 14.08.2014
International Application No. PCT/US2014/015744
International Filing Date 11.02.2014
IPC
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
551
the carrier being inorganic
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/551 (2006.01)
G01N 33/574 (2006.01)
G01N 33/50 (2006.01)
CPC
A61K 2039/5154
A61K 2039/55555
A61K 31/555
A61K 39/0011
A61K 41/0057
A61K 41/0071
Applicants
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; Boyd Graduate Studies Research Center Athens, GA 30602-7411, US
Inventors
  • DHAR, Shanta; US
  • MARRACHE, Sean; US
  • HARN, Donald, A.; US
  • TUNDUP, Smanla; US
Agents
  • CAMPBELL, Keith, M.; Mueting Raasch & Gebhardt, P.A. P.O. Box 581336 Minneapolis, MN 55458-1336, US
Priority Data
61/763,40811.02.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENERATION OF FUNCTIONAL DENDRITIC CELLS
(FR) GÉNÉRATION DE CELLULES DENDRITIQUES FONCTIONNELLES
Abstract
(EN)
Nanoparticles containing a photosensitizer configured to generate a reactive oxygen species when exposed to an appropriate wavelength of light can be used to enhance immunogenicity of cancer cells, such as breast cancer cells. Such enhanced immunogenicity cancer cells, or supernatants thereof, can be used to activate dendritic cells or cause dendritic cells to produce INF-gamma. Nanoparticles having mitochondria-targeting moieties are more effective at enhancing the immunogenicity of the cancer cells, or causing the dendritic cells to produce IFN-gamma, than nanoparticle lacking mitochondria-targeting moieties or free photosensitizer.
(FR)
L'invention concerne des nanoparticules contenant un photosensibiliseur configuré pour générer des espèces réactives de l'oxygène lorsqu'il est exposé à une longueur d'onde appropriée de lumière qui peut être utilisée pour améliorer l'immunogénicité des cellules cancéreuses, telles que des cellules cancéreuses du sein. De telles cellules cancéreuses à immunogénicité accrue ou des surnageants de celles-ci peuvent être utilisé(e)s pour activer des cellules dendritiques ou entraîner les cellules dendritiques à produire de l'IFN gamma. Les nanoparticules ayant des fractions de ciblage de mitochondries sont plus efficaces à augmenter d'immunogénicité des cellules cancéreuses, ou à entraîner les cellules dendritiques à produire l'IFN-gamma, que des nanoparticules dépourvues de fractions de ciblage de mitochondries ou sans photosensibiliseur.
Also published as
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