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1. WO2014123859 - DIGITAL HOLOGRAPHIC MICROSCOPY APPARATUS AND METHOD FOR CLINICAL DIAGNOSTIC HEMATOLOGY

Publication Number WO/2014/123859
Publication Date 14.08.2014
International Application No. PCT/US2014/014595
International Filing Date 04.02.2014
IPC
G01B 9/021 2006.1
GPHYSICS
01MEASURING; TESTING
BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
9Instruments as specified in the subgroups and characterised by the use of optical measuring means
02Interferometers
021using holographic techniques
G01B 9/04 2006.1
GPHYSICS
01MEASURING; TESTING
BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
9Instruments as specified in the subgroups and characterised by the use of optical measuring means
04Measuring microscopes
G01N 33/46 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
46Wood
CPC
G01N 15/0227
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
02Investigating particle size or size distribution
0205by optical means, e.g. by light scattering, diffraction, holography or imaging
0227using imaging, e.g. a projected image of suspension; using holography
G01N 2015/0065
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
0065biological, e.g. blood
G01N 2015/0233
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
02Investigating particle size or size distribution
0205by optical means, e.g. by light scattering, diffraction, holography or imaging
0233using holography
G02B 21/365
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
36arranged for photographic purposes or projection purposes
365Control or image processing arrangements for digital or video microscopes
Applicants
  • WET LABS, INC. [US]/[US]
Inventors
  • TWARDOWSKI, Michael Stewart
  • SULLIVAN, James Michael
Agents
  • RADIGAN, Kevin P.
Priority Data
61/760,79305.02.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIGITAL HOLOGRAPHIC MICROSCOPY APPARATUS AND METHOD FOR CLINICAL DIAGNOSTIC HEMATOLOGY
(FR) APPAREIL DE MICROSCOPIE HOLOGRAPHIQUE DIGITALE ET PROCÉDÉ POUR HÉMATOLOGIE DIAGNOSTIC CLINIQUE
Abstract
(EN) An apparatus, method, and apparatus for hematology analysis comprising using a holographic microscope, in one embodiment a transmission-type holographic microscope. In one aspect, laser light is provided and split into first and second sample beams, the first sample beam for imaging with a first magnification, the second sample beam for imaging with a second magnification. The first and second sample beams are passed through a sample volume requiring hematology analysis. The first and second sample beams are combined with a reference beam and captured for digital analysis. The present invention enables adequate blood cell type differentials with a single, easily implemented, cost-effective holographic technique.
(FR) L'invention concerne un appareil, un procédé et un appareil d'analyse hématologique consistant à utiliser un microscope holographique, dans un mode de réalisation, un microscope holographique de type à transmission. Dans un aspect de l'invention, une lumière laser est utilisée et se divise en des premier et second faisceaux témoins, Le premier faisceau témoin pour exécuter une imagerie avec un premier grossissement, le second faisceau témoin pour exécuter une imagerie avec un second grossissement. Les premier et second faisceaux témoins traversent un volume d'échantillon nécessitant une analyse hématologique. Les premier et second faisceaux témoins sont combinés avec un faisceau de référence et capturés en vue d'une analyse digitale. Le mode de réalisation de l'invention permet une différentiation adéquate du type de cellules sanguines avec une technique holographique peu coûteuse, simple et facilement réalisable.
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