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1. WO2014122183 - MUSCARINIC ACETYLCHOLINE RECEPTOR BINDING AGENTS AND USES THEREOF

Publication Number WO/2014/122183
Publication Date 14.08.2014
International Application No. PCT/EP2014/052265
International Filing Date 05.02.2014
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 2317/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
22from camelids, e.g. camel, llama or dromedary
C07K 2317/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
32specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
C07K 2317/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
C07K 2317/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Applicants
  • VIB VZW [BE]/[BE]
  • VRIJE UNIVERSITEIT BRUSSEL [BE]/[BE]
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • STEYAERT, Jan
  • PARDON, Els
  • KOBILKA, Brian
  • RING, Aaron
  • KRUSE, Andrew
  • MANGLIK, Aasish
Common Representative
  • VIB VZW
Priority Data
61/761,13605.02.2013US
61/961,05803.10.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MUSCARINIC ACETYLCHOLINE RECEPTOR BINDING AGENTS AND USES THEREOF
(FR) AGENTS SE LIANT AUX RÉCEPTEURS MUSCARINIQUES DE L'ACÉTYLCHOLINE ET LEURS UTILISATIONS
Abstract
(EN) Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally-specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure based drug design.
(FR) Cette invention concerne des agents qui se lient spécifiquement à un récepteur muscarinique de l'acétylcholine de façon spécifique de la conformation et qui peuvent être utilisés pour induire un changement conformationnel dans le récepteur. Ces agents ont des applications thérapeutiques et peuvent être utilisés dans des études de cristallographie aux rayons X du récepteur. Ils peuvent également être utilisés pour améliorer la découverte de médicaments par criblage de composés et/ou conception de médicaments basée sur la structure.
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