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1. WO2014119633 - THERAPEUTIC AGENT FOR CARDIAC TAMPONADE

Publication Number WO/2014/119633
Publication Date 07.08.2014
International Application No. PCT/JP2014/052015
International Filing Date 30.01.2014
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07K 7/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Applicants
  • 株式会社蛋白科学研究所 RESEARCH INSTITUTE FOR PROTEIN SCIENCE CO. [JP]/[JP]
Inventors
  • 岡田 秀親 OKADA Hidechika
  • ミハイ ボロス MIHALY Boros
  • ダニエル エルシーズ DANIEL Erces
Agents
  • 今井 豊 IMAI Yutaka
Priority Data
2013-01740931.01.2013JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) THERAPEUTIC AGENT FOR CARDIAC TAMPONADE
(FR) AGENT THÉRAPEUTIQUE POUR TAMPONNADE CARDIAQUE
(JA) 心タンポナーデ治療薬
Abstract
(EN) [Problem] To provide a therapeutic agent for cardiac tamponade, said therapeutic agent controlling the occurrence of complications accompanying cardiac tamponade by preventing or alleviating the worsening of macrocirculation and microcirculation, said worsening occurring as a result of cardiac tamponade, and by controlling local and systemic inflammation which are associated with the worsening of said types of circulation. [Solution] A pharmaceutical which contains a peptide of the present invention or a pharmaceutically acceptable salt of said peptide as an active ingredient. The pharmaceutical is useful as a therapeutic agent for cardiac tamponade (pericardial tamponade) caused by a myocardial infarction, malignant tumour metastasis, collagen disease, or the like.
(FR) La présente invention vise à proposer un agent thérapeutique pour tamponnade cardiaque, ledit agent thérapeutique supprimant l'apparition de complications accompagnant une tamponnade cardiaque en empêchant ou en atténuant l'aggravation de macrocirculation et de microcirculation, ladite aggravation survenant à la suite d'une tamponnade cardiaque, et en supprimant des inflammations locales et systémiques qui sont associées à l'aggravation desdits types de circulation. A cet effet, l'invention concerne un agent pharmaceutique, qui contient un peptide de la présente invention ou un sel pharmaceutiquement acceptable dudit peptide en tant que principe actif. L'agent pharmaceutique est utile en tant qu'agent thérapeutique pour une tamponnade cardiaque (tamponnade péricardique) causée par un infarctus du myocarde, une métastase de tumeur maligne, une maladie du collagène ou analogue.
(JA) 【課題】本発明は、心タンポナーデにより生ずるマクロ循環及び微小循環の悪化を防止・改善し、且つこれらの循環の悪化に付随する局所性及び全身性の炎症を抑制することにより、心タンポナーデに伴う合併症の発生を抑制する心タンポナーデ治療薬を提供する。 【解決手段】本発明におけるペプチド又はその製薬上許容される塩を有効成分として含有する医薬は、心筋梗塞、悪性腫瘍転移、膠原病等が原因となって生じる心タンポナーデ(心膜タンポナーデ)の治療剤として有用である。
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