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1. WO2014115167 - NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION

Publication Number WO/2014/115167
Publication Date 31.07.2014
International Application No. PCT/IN2014/000048
International Filing Date 23.01.2014
IPC
A61K 31/56 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
C07J 71/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopentahydrophenanthrene skeleton is condensed with a heterocyclic ring
C07J 5/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
5Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
04for throat disorders
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
Applicants
  • SPHAERA PHARMA PVT. LTD. [IN]/[IN]
Inventors
  • DUGAR, Sundeep
  • SCHREINER, Frederic, George
  • MAHAJAN, Dinesh
  • SHARMA, Amit
  • PATIL, Ishwar, Rakesh
  • KUILA, Bilash
Agents
  • ARVIND, Chitra
Priority Data
173/DEL/201323.01.2013IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION
(FR) NOUVEAUX COMPOSÉS DE 11BÊTA-HYDROXY-STÉROÏDES DESTINÉS À ÊTRE UTILISÉS UTILISATION DANS LA BIOGENÈSE DE MITOCHONDRIES ET LES MALADIES ASSOCIÉES AVEC LA DYSFONCTION OU LA DÉPLÉTION MITOCHONDRIALE
Abstract
(EN) The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.
(FR) La présente invention concerne des nouveaux composés de 11β-hydroxy stéroïdes et des compositions et leur application comme produits pharmaceutiques pour prévenir ou inverser une lésion aux mitochondries, pour traiter ou prévenir les maladies associées à la dysfonction ou la déplétion mitochondriale, et pour induire une régénération ou une restructuration de mitochondries comme moyen de traitement de maladies associées à des anomalies dans la structure et la fonction mitochondriales chez un sujet humain ou animal. L'invention concerne également des procédés pour diagnostiquer une lésion aux mitochondries et pour diagnostiquer le succès ou l'échec de thérapies conçues pour traiter, prévenir ou inverser une lésion à ou une déplétion de mitochondries.
Latest bibliographic data on file with the International Bureau