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1. WO2014115011 - COMPOSITIONS FOR USE IN TREATING EYE DISORDERS USING OPIOID RECEPTOR ANTAGONISTS

Publication Number WO/2014/115011
Publication Date 31.07.2014
International Application No. PCT/IB2013/061461
International Filing Date 31.12.2013
IPC
A61K 31/485 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
CPC
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Applicants
  • REMEDEYE INC [US]/[US]
Inventors
  • ROGOSNITZKY, Moshe
Priority Data
22442227.01.2013IL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS FOR USE IN TREATING EYE DISORDERS USING OPIOID RECEPTOR ANTAGONISTS
(FR) COMPOSITIONS POUR UTILISATION DANS LE TRAITEMENT DE TROUBLES OCULAIRES AU MOYEN D’ANTAGONISTES DE RÉCEPTEUR OPIOÏDE
Abstract
(EN)
Compositions for use in treating eye disorders using opioid receptor antagonists include an effective amount of a topically-administered opioid receptor antagonist, the topically-administered opioid receptor antagonist formulated as a solution, wherein the topically-administered opioid receptor antagonist is selected from the group consisting of: naltrexone, naloxone, nalmefene, and a pharmaceutically- acceptable salt thereof. The effective amount corresponds to a concentration of at least about 10 -7 molarity, and is based on a treatment administration of at least once every other day.
(FR)
La présente invention concerne des compositions pour utilisation dans le traitement de troubles oculaires au moyen d’antagonistes de récepteur opioïde qui comprennent une quantité efficace d’un antagoniste de récepteur opioïde administré de façon topique, l’antagoniste de récepteur opioïde administré de façon topique formulé sous forme de solution étant choisi dans le groupe constitué de : naltrexone, naloxone, nalméfène, et un sel pharmaceutiquement acceptable de celui-ci. La quantité efficace correspond à une concentration molaire d’au moins environ 10-7, et est basée sur une administration de traitement au moins un jour sur deux.
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