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3. WO2014112902 - PEPTIDE INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

Publication Number WO/2014/112902
Publication Date 24.07.2014
International Application No. PCT/RU2014/000032
International Filing Date 20.01.2014
IPC
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61K 38/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 8/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts, esters or N-acylated derivatives thereof
A61K 8/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
A61K 8/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
A61Q 19/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
08Anti-ageing preparations
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61Q 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
08Anti-ageing preparations
C07K 14/70571
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70571for neuromediators, e.g. serotonin receptor, dopamine receptor
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • LIMITED LIABILITY COMPANY "SYNEURO [RU]/[RU]
Inventors
  • ZHMAK, Maxim Nurgayanovich
  • UTKIN, Yury Nikolaevich
  • ANDREEVA, Tatyana Viktorovna
  • KUDRYAVTSEV, Denis Sergeevich
  • KRYUKOVA, Elena Viktorovna
  • TSETLIN, Viktor Ionovich
  • KASHEVEROV, Igor Evgen`evich
  • STARKOV, Vladislav Gennad`evich
  • SHELUKHINA, Irina Valer`evna
Priority Data
201310241021.01.2013RU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDE INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTOR
(FR) INHIBITEURS PEPTIDIQUES DU RÉCEPTEUR NICOTINIQUE DE L'ACÉTYLCHOLINE
Abstract
(EN)
The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine receptor. The claimed compounds have common formula (I): X1-X2-X3-Pro-X4-X5-X6, where X1 is chosen within H, Ac-, Palm-; X2 is chosen within Trp, Tyr, His, Phe, Pro; X3 is chosen within Trp, Tyr, His, Phe, Lys, Om, Dbu, Dpr, Arg; X5 is chosen within Trp, Tyr, His, Phe, Pro; X6 is chosen within -OH, -NH2, -OCH3, -OC2H5, -NH-C6H5. The invention can be applied in cosmetics for smoothing mimic and age-related wrinkles.
(FR)
La présente invention concerne le domaine de la biochimie, en particulier de nouveaux composés peptidiques capables du blocage sélectif du récepteur nicotinique de l'acétylcholine du type musculaire. Les composés selon la présente invention sont représentés par la formule commune (I) X1-X2-X3-Pro-X4-X5-X6, dans laquelle X1 est choisi parmi H, Ac-, Palm-; X2 est choisi parmi Trp, Tyr, His, Phe, Pro; X3 est choisi parmi Trp, Tyr, His, Phe, Lys, Om, Dbu, Dpr, Arg; X5 est choisi parmi Trp, Tyr, His, Phe, Pro; X6 est choisi parmi -OH, -NH2, -OCH3, -OC2H5, -NH-C6H5. L'invention peut être appliquée dans des produits cosmétiques pour le lissage des rides mimiques et liées à l'âge.
Also published as
Latest bibliographic data on file with the International Bureau