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1. WO2014110705 - HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

Publication Number WO/2014/110705
Publication Date 24.07.2014
International Application No. PCT/CN2013/001676
International Filing Date 31.12.2013
IPC
C07D 498/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 409/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/5365 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365ortho- or peri-condensed with heterocyclic ring systems
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365ortho- or peri-condensed with heterocyclic ring systems
A61K 31/7056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
7056containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/7072
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • YU, Wensheng [CN]/[US] (US)
  • TONG, Ling [CN]/[US] (US)
  • KOZLOWSKI, Joseph A. [US]/[US] (US)
  • SELYUTIN, Oleg [US]/[US] (US)
  • CHEN, Lei [CN]/[US] (US)
  • KIM, Jae-Hun [KR]/[US] (US)
  • SHA, Deyou [US]/[US] (US)
  • RIZVI, Razia [US]/[US] (US)
  • SHANKAR, Bandarpalle [US]/[US] (US)
  • HU, Bin [CN]/[CN] (US)
  • ZHONG, Bin [CN]/[CN] (US)
  • WANG, Dahai [CN]/[CN] (US)
  • HAO, Jinglai [CN]/[CN] (US)
  • WEI, Wei [CN]/[CN] (US)
  • JI, Tao [CN]/[CN] (US)
  • ZAN, Shuai [CN]/[CN] (US)
Inventors
  • YU, Wensheng
  • TONG, Ling
  • KOZLOWSKI, Joseph A.
  • SELYUTIN, Oleg
  • CHEN, Lei
  • KIM, Jae-Hun
  • SHA, Deyou
  • RIZVI, Razia
  • SHANKAR, Bandarpalle
  • HU, Bin
  • ZHONG, Bin
  • WANG, Dahai
  • HAO, Jinglai
  • WEI, Wei
  • JI, Tao
  • ZAN, Shuai
Agents
  • WU, FENG & ZHANG CO.
Priority Data
PCT/CN2013/00003816.01.2013CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES
(FR) COMPOSÉS TÉTRACYCLIQUES SUBSTITUÉS PAR UN HÉTÉROCYCLE ET PROCÉDÉS POUR LES UTILISER POUR LE TRAITEMENT DE MALADIES VIRALES
Abstract
(EN) The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3, R 4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
(FR) La présente invention concerne de nouveaux composés tétracycliques substitués par un hétérocycle de formule (I): (I) et leurs sels pharmaceutiquement acceptables, où A, A', R2, R3, R4 et R sont définis ici. La présente invention concerne également des compositions comprenant au moins un composé tétracyclique substitué par un hétérocycle et des procédés d'utilisation des composés tétracycliques substitués par un hétérocycle pour traiter ou prévenir une infection par le VHC chez un patient.
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