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1. WO2014107731 - THERAPEUTIC VACCINES FOR TREATING HERPES SIMPLEX VIRUS TYPE 2 INFECTIONS

Publication Number WO/2014/107731
Publication Date 10.07.2014
International Application No. PCT/US2014/010516
International Filing Date 07.01.2014
IPC
A61K 39/245 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
A61K 9/127 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
CPC
A61K 2039/543
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
543intranasal
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
Applicants
  • BIOMEDICAL RESEARCH MODELS, INC. [US]/[US]
Inventors
  • YANG, Kejian
  • GUBERSKI, Dennis L.
Agents
  • MCLEOD, Bonnie Weiss
Priority Data
61/749,68207.01.2013US
61/799,55215.03.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC VACCINES FOR TREATING HERPES SIMPLEX VIRUS TYPE 2 INFECTIONS
(FR) VACCINS THÉRAPEUTIQUES PERMETTANT DE TRAITER LES INFECTIONS PAR LE VIRUS DE L'HERPÈS SIMPLEX DE TYPE 2
Abstract
(EN) The invention provides methods and kits for inducing a therapeutic immunity in animals (e.g. mammals) against viral antigens, including herpes-simplex virus type 2. In particular, the invention provides a method of treating animals with an established HSV-2 infection by administering a therapeutic vaccine comprising a priming dose of a nucleic acid encoding an HSV-2 antigen, an initial or first boosting dose comprising the protein form of the antigen encapsulated in liposomes, and one or more subsequent boosting doses comprising both the nucleic acid encoding the HSV-2 antigen and the liposomal-encapsulated protein antigen.
(FR) La présente invention concerne des méthodes et des nécessaires visant à induire une immunité thérapeutique chez des animaux (par exemple des mammifères) contre des antigènes viraux et, notamment, contre le virus de l'herpès simplex de type 2 (VHS-2). L'invention concerne, en particulier, une méthode de traitement d'animaux souffrant d'une infection établie par le VHS-2, qui implique l'administration d'un vaccin thérapeutique comprenant une dose d'amorçage à base d'un acide nucléique codant pour un antigène du VHS-2, une dose initiale ou une première dose de rappel contenant la forme protéique de l'antigène encapsulée dans des liposomes et une ou plusieurs doses de rappel ultérieures contenant à la fois l'acide nucléique codant pour l'antigène du VHS-2 et l'antigène protéique encapsulé dans des liposomes.
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