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1. (WO2014100323) POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/100323 International Application No.: PCT/US2013/076367
Publication Date: 26.06.2014 International Filing Date: 19.12.2013
IPC:
C07D 498/14 (2006.01) ,C07D 471/04 (2006.01) ,C07D 471/14 (2006.01) ,C07D 471/22 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
22
in which the condensed systems contains four or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, CA 94404, US
Inventors:
JIN, Haolun; US
LAZERWITH, Scott, E.; US
MARTIN, Teresa, Alejandra, Trejo; US
BACON, Elizabeth, M.; US
COTTELL, Jeromy, J.; US
CAI, Zhenhong, R.; US
PYUN, Hyung-Jung; US
MORGANELLI, Philip, Anthony; US
JI, Mingzhe; US
TAYLOR, James, G.; US
CHEN, Xiaowu; US
MISH, Michael, R.; US
DESAI, Manoj, C.; US
Agent:
WAGNER, Emily, W.; Cooley LLP 1299 Pennsylvania Avenue, NW Suite 700 Washington, DC 20004, US
Priority Data:
61/745,37521.12.2012US
61/788,39715.03.2013US
61/845,80312.07.2013US
Title (EN) POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
(FR) COMPOSÉS DE CARBAMOYLPYRIDONE POLYCYCLIQUES ET LEUR UTILISATION PHARMACEUTIQUE
Abstract:
(EN) Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Ζ1 and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
(FR) La présente invention concerne des composés pour utilisation dans le traitement du virus de l’immunodéficience humaine (VIH). Les composés ont la formule suivante (I) : comprenant les stéréoisomères et les sels pharmaceutiquement acceptables de ceux-ci, où R1, X, W, Y1, Y2, Ζ1 et Z4 sont tels que définis dans la description. La présente invention concerne en outre des procédés associés à la préparation et l’utilisation de ces composés, ainsi que des compositions pharmaceutiques comprenant de tels composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MD6255MDa 2015 0064MDa 2017 0067RSP-2016/0407EP2822954CA2893843
KR1020150096504SG11201504857SCN104995198BR112015014714JP2016508134BR122015029881
ES2577283EA201591027EP3067358NZ709260IL239316IL245780
DK2822954AU2013361401KR1020170073733VN44561ID2017/01023MYPI 2015001580
PH1/2015/501445VN45301IN5535/DELNP/2015TH174304PH1/2016/500389CR20170279