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1. (WO2014097147) TRICYCLIC COMPOUNDS AS CFTR INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/097147 International Application No.: PCT/IB2013/061041
Publication Date: 26.06.2014 International Filing Date: 17.12.2013
IPC:
C07D 487/14 (2006.01) ,C07D 498/14 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/5383 (2006.01) ,A61P 1/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5383
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
12
Antidiarrhoeals
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
AHMED, Mahbub [GB/GB]; GB (US)
ASHALL-KELLY, Alexander [GB/GB]; GB (US)
BLOOMFIELD, Graham Charles [GB/GB]; GB (US)
GUERITZ, Louisa [GB/GB]; GB (US)
MCKENNA, Jeffrey [GB/GB]; GB (US)
MCKENNA, Joseph [GB/GB]; GB (US)
MUTTON, Simon [GB/GB]; GB (US)
PARMAR, Rakesh [GB/GB]; GB (US)
SHEPHERD, Jon [GB/GB]; GB (US)
WRIGHT, Paul [GB/GB]; GB (US)
Inventors:
AHMED, Mahbub; GB
ASHALL-KELLY, Alexander; GB
BLOOMFIELD, Graham Charles; GB
GUERITZ, Louisa; GB
MCKENNA, Jeffrey; GB
MCKENNA, Joseph; GB
MUTTON, Simon; GB
PARMAR, Rakesh; GB
SHEPHERD, Jon; GB
WRIGHT, Paul; GB
Common
Representative:
NOVARTIS AG; Lichtstrasse 35 CH-4056 Basel, CH
Priority Data:
61/739,33719.12.2012US
61/906,15419.11.2013US
Title (EN) TRICYCLIC COMPOUNDS AS CFTR INHIBITORS
(FR) COMPOSÉS TRICYCLIQUES UTILISÉS COMME INHIBITEURS DU CFTR
Abstract:
(EN) The present invention provides a CFTR inhibitor of formula (I) or a pharmaceutically acceptable salt thereof; and its therapeutic uses, e.g. in the treatment of diarrhea. The present invention further provides a combination of pharmacological active agents and a pharmaceutical composition.
(FR) L'invention concerne un inhibiteur du CFTR de formule (I) ou son sel pharmaceutiquement acceptable, et ses utilisations thérapeutiques, par exemple pour traiter la diarrhée. La présente invention porte en outre sur une combinaison d'agents pharmacologiques actifs et sur une composition pharmaceutique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2895656KR1020150095925EP2935277CN105008370EA201591175JP2016507498
AU2013365827BR112015014433ES2650372IN5307/DELNP/2015