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1. WO2014093595 - CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

Publication Number WO/2014/093595
Publication Date 19.06.2014
International Application No. PCT/US2013/074611
International Filing Date 12.12.2013
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12N 15/63 (2006.01)
CPC
C12N 15/102
C12N 15/1082
C12N 15/113
C12N 15/63
C12N 15/70
C12N 15/74
Applicants
  • THE BROAD INSTITUTE, INC. [US/US]; 415 Main Street Cambridge, MA 02142, US
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02142, US
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138, US
  • THE ROCKEFELLER UNIVERSITY [US/US]; 1230 York Ave. New York, NY 10065, US
Inventors
  • ZHANG, Feng; US
  • BIKARD, David, Olivier; US
  • CONG, Le; US
  • COX, David Benjamin, Turitz; US
  • HSU, Patrick; US
  • JIANG, Wenyan; US
  • LIN, Shauiliang; US
  • MARRAFFINI, Luciano; US
  • PLATT, Randall, Jeffrey; US
  • RAN, Fei; US
  • SANJANA, Neville, Espi; US
Agents
  • KOWALSKI, Thomas, J.; Vedder Price P.C. 1633 Broadway New York, NY 10019, US
Priority Data
61/736,52712.12.2012US
61/748,42702.01.2013US
61/768,95925.02.2013US
61/791,40915.03.2013US
61/835,93117.06.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
(FR) SYSTÈMES DE COMPOSANTS DE CRISPR-CAS, PROCÉDÉS ET COMPOSITIONS POUR LA MANIPULATION DE SÉQUENCES
Abstract
(EN)
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.
(FR)
L'invention concerne des systèmes, des procédés et des compositions pour la manipulation de séquences et/ou d'activités de séquences cibles. Elle concerne des vecteurs et des systèmes de vecteur, dont certains codent un ou plusieurs composants d'un complexe CRISPR, ainsi que des procédés pour la conception et l'utilisation de ces vecteurs. Elle concerne également des procédés pour diriger la formation de complexes CRISPR dans des cellules eucaryotes et des procédés pour sélectionner des cellules spécifiques par introduction de mutations précises en utilisant le système CRISPR/Cas.
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