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1. WO2014090053 - MONOCLONAL ANTIBODY FOR ANTAGONIZING AND INHIBITING BINDING OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR AND ITS RECEPTOR, AND CODING SEQUENCE AND USE THEREOF

Publication Number WO/2014/090053
Publication Date 19.06.2014
International Application No. PCT/CN2013/086542
International Filing Date 05.11.2013
IPC
C07K 16/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
C12N 15/63 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39558against tumor tissues, cells, antigens
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
C07K 14/515
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
515Angiogenesic factors; Angiogenin
Applicants
  • 苏州思坦维生物技术有限责任公司 SUZHOU STAINWEI BIOTECH INC. [CN]/[CN]
Inventors
  • 罗师平 LUO, Shiping
  • 胡红群 HU, Hongqun
  • 陈蕞 CHEN, Zui
  • 蔡明文 CAI, Mingwen
  • 孙亚男 SUN, Yanan
  • 刘海云 LIU, Haiyun
  • 周建鹰 ZHOU, Jianying
  • 宋晓琦 SONG, Xiaoqi
  • 平小芽 PING, Xiaoya
  • 陈思宇 CHEN, Siyu
  • 石东红 SHI, Donghong
  • 徐一清 XU, Yiqing
  • 周群敏 ZHOU, Qunmin
Agents
  • 上海浦一知识产权代理有限公司 DING & ASSOCIATES PATENT TRADEMARK & LAW
Priority Data
201210543652.014.12.2012CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MONOCLONAL ANTIBODY FOR ANTAGONIZING AND INHIBITING BINDING OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR AND ITS RECEPTOR, AND CODING SEQUENCE AND USE THEREOF
(FR) ANTICORPS MONOCLONAL POUR L'ANTAGONISATION ET L'INHIBITION DE LA LIAISON DU FACTEUR DE CROISSANCE CELLULAIRE ENDOTHÉLIAL VASCULAIRE ET DE SON RÉCEPTEUR, ET SA SÉQUENCE CODANTE ET SON UTILISATION
(ZH) 拮抗抑制血管内皮细胞生长因子与其受体结合的单克隆抗体及其编码序列与用途
Abstract
(EN) Disclosed in the present invention are a mouse monoclonal antibody for antagonizing and inhibiting binding of a vascular endothelial cell growth factor (VEGF) and its receptor (VEGF-R), and a heavy chain variable region and light chain variable region amino acid sequence thereof. Also disclosed in the present invention are a humanized preparation process of the antibody and a heavy chain variable region and light chain variable region amino acid sequence of the humanized antibody. The humanized antibody or its derivative can act as a ingredient of a pharmaceutical composition or be prepared into a suitable pharmaceutical preparation, is administered alone or in combination with a chemotherapy drug or other treatment means, and is used in broad-spectrum treatment of various solid tumors such as colon cancer, breast cancer and rhabdomyosarcoma.
(FR) La présente invention concerne un anticorps monoclonal murin pour l'antagonisation et l'inhibition de la liaison d'un facteur de croissance cellulaire endothélial vasculaire (VEGF) et de son récepteur (VEGF-R), et une séquence d'acides aminés de région variable de chaîne lourde et de région variable de chaîne légère associée. La présente invention concerne également un procédé de préparation humanisé de l'anticorps et une séquence d'acides aminés de région variable de chaîne lourde et de région variable de chaîne légère de l'anticorps humanisé. L'anticorps humanisé ou son dérivé peut agir en tant qu'ingrédient d'une composition pharmaceutique ou être préparé en une préparation pharmaceutique appropriée, est administré seul ou en combinaison avec un médicament chimio-thérapeutique ou d'autres moyens de traitement, et est utilisé dans un traitement à large spectre de diverses tumeurs solides, telles que le cancer du côlon, le cancer du sein et un rhabdomyosarcome.
(ZH) 本发明公开了一种拮抗抑制血管内皮细胞生长因子(VEGF)与其受体(VEGF-R)结合的小鼠单克隆抗体及其重链可变区与轻链可变区氨基酸序列。本发明还公开了该抗体的人源化制备过程及该人源化抗体重链可变区与轻链可变区氨基酸序列。该人源化抗体或其衍生体可作为药物组合物成分或制备成合适药物制剂,单独给药或与化疗药物等其他治疗手段合并使用,用于广谱治疗结肠癌、乳腺癌、横纹肌肉瘤等各种实体瘤。
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