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1. WO2014086852 - PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

Publication Number WO/2014/086852
Publication Date 12.06.2014
International Application No. PCT/EP2013/075526
International Filing Date 04.12.2013
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4748
forming part of bridged ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C07D 401/12 (2006.01)
A61K 31/4427 (2006.01)
C07D 453/00 (2006.01)
A61K 31/4748 (2006.01)
C07D 401/14 (2006.01)
CPC
A61K 31/439
A61K 9/0075
C07D 401/12
C07D 401/14
C07D 453/00
C07D 453/02
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT
Inventors
  • AMARI, Gabriele; IT
  • ARMANI, Elisabetta; IT
  • RICCABONI, Mauro; IT
  • RIZZI, Andrea; IT
  • BAKER-GLENN, Charles; IT
  • BLACKABY, Wesley; IT
  • VAN DE PÖEL, Hervé; IT
  • WHITTAKER, Ben; IT
Agents
  • MINOJA, Fabrizio; Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 I-20129 Milano, IT
Priority Data
12195725.205.12.2012EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS
(FR) DÉRIVÉS DE PHÉNYLÉTHYLPYRIDINE COMME INHIBITEURS DE PDE4
Abstract
(EN)
The invention relates to novel compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
(FR)
La présente invention concerne de nouveaux composés qui sont des inhibiteurs de l'enzyme phosphodiestérase 4 (PDE4) et des antagonistes des récepteurs muscariniques M3, des procédés de préparation desdits composés, des compositions les contenant et leur utilisation thérapeutique.
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