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1. WO2014085947 - CHEMOKINE-CYTOKINE FUSION PROTEIN AND APPLICATION THEREOF

Publication Number WO/2014/085947
Publication Date 12.06.2014
International Application No. PCT/CN2012/001629
International Filing Date 05.12.2012
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 14/52 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 14/525 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
525Tumour necrosis factor (TNF)
C07K 14/54 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
C12N 15/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
CPC
A61K 2039/55533
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55522Cytokines; Lymphokines; Interferons
55527Interleukins
55533IL-2
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
C07K 14/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 14/521
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
521Chemokines
C07K 14/522
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
521Chemokines
522Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
C07K 14/525
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
525Tumour necrosis factor [TNF]
Applicants
  • 邱绣河 CHIOU, Shiow-Her [CN]/[CN]
Inventors
  • 邱绣河 CHIOU, Shiow-Her
  • 周宽基 CHOW, Kuan-Chih
  • 沈瑞鸿 SHIEN, Jui-Hung
  • 范怡馨 FAN, Yi-Hsin
  • 林佩桦 LIN, Pei-Hua
  • 吴佩珊 WU, Pei-Shan
Agents
  • 北京科龙寰宇知识产权代理有限责任公司 KELONG INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD.
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CHEMOKINE-CYTOKINE FUSION PROTEIN AND APPLICATION THEREOF
(FR) PROTÉINE DE FUSION CHIMIOKINE-CYTOKINE ET SON UTILISATION
(ZH) 趋化素-细胞素融合蛋白和其应用
Abstract
(EN)
The present invention provides a fusion protein comprising the chemokine polypeptide which is a chemokine or receptor-binding domain thereof, and the cytokine polypeptide linked to said chemokine polypeptide, the cytokine polypeptide is an interleukin, a TNF-superfamily cytokine or receptor-binding domain thereof, the chemokine polypeptide and the cytokine polypeptide possess same target cells, and the fusion protein has enhanced chemokine activity comparing with said chemokine polypeptide and enhanced cytokine activity comparing with said cytokine polypeptide.
(FR)
La présente invention concerne une protéine de fusion comprenant un polypeptide de type chimiokine qui est une chimiokine à proprement parler ou le domaine de liaison du récepteur de celle-ci, et un polypeptide de type cytokine lié audit polypeptide de type chimiokine, le polypeptide de type cytokine étant une interleukine, une cytokine de la super-famille du TNF ou le domaine de liaison du récepteur de celle-ci. Le polypeptide de type chimiokine et le polypeptide de type cytokine possèdent les mêmes cellules cibles et ladite protéine de fusion présente une activité chimiokine renforcée par rapport à celle du polypeptide de type chimiokine et une activité cytokine renforcée par rapport à celle du polypeptide de type cytokine.
(ZH)
本发明提供一种融合蛋白,其包含趋化素多肽,其为一趋化素或其受体结合域;和连接至该趋化素多肽的细胞素多肽,其为一介白素、一 TNF-超家族细胞素或其受体结合域;其中该趋化素多肽和该细胞素多肽具有共同的标的细胞,且该融合蛋白具有相较于该趋化素多肽的增进的趋化素活性,以及相较于该细胞素多肽的增进的细胞素活性。
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