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1. WO2014083109 - PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS

Publication Number WO/2014/083109
Publication Date 05.06.2014
International Application No. PCT/EP2013/074974
International Filing Date 28.11.2013
IPC
B01J 31/06 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
02containing organic compounds or metal hydrides
06containing polymers
B01J 31/16 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
16containing coordination complexes
B01J 31/24 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
16containing coordination complexes
24Phosphines
C08G 77/385 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04Polysiloxanes
38Polysiloxanes modified by chemical after-treatment
382containing atoms other than carbon, hydrogen, oxygen or silicon
385containing halogens
C08G 77/388 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04Polysiloxanes
38Polysiloxanes modified by chemical after-treatment
382containing atoms other than carbon, hydrogen, oxygen or silicon
388containing nitrogen
C08G 77/392 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04Polysiloxanes
38Polysiloxanes modified by chemical after-treatment
382containing atoms other than carbon, hydrogen, oxygen or silicon
392containing sulfur
CPC
B01J 20/26
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
22comprising organic material
26Synthetic macromolecular compounds
B01J 2231/321
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2231Catalytic reactions performed with catalysts classified in B01J31/00
30Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
32Addition reactions to C=C or C-C triple bonds
321Hydroformylation, metalformylation, carbonylation or hydroaminomethylation
B01J 2231/42
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2231Catalytic reactions performed with catalysts classified in B01J31/00
40Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
42Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
B01J 2231/4211
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2231Catalytic reactions performed with catalysts classified in B01J31/00
40Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
42Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
4205C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
4211Suzuki-type, i.e. RY + R'B(OR)2, in which R, R' are optionally substituted alkyl, alkenyl, aryl, acyl and Y is the leaving group
B01J 2531/0205
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2531Additional information regarding catalytic systems classified in B01J31/00
02Compositional aspects of complexes used, e.g. polynuclearity
0202Polynuclearity
0205Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
B01J 2531/16
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2531Additional information regarding catalytic systems classified in B01J31/00
10Complexes comprising metals of Group I (IA or IB) as the central metal
16Copper
Applicants
  • PHOSPHONICS LTD [GB]/[GB]
  • MURRAY, Paul [IE]/[GB]
Inventors
  • MURRAY, Paul
  • WILKES, Robin
  • NORTH, Christopher
Agents
  • GEARY, Stephen
Priority Data
1221402.928.11.2012GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS
(FR) PROCÉDÉ POUR LE RETRAIT D'UN CATALYSEUR D'UN MILIEU EN PHASE LIQUIDE ET SON RENVOI VERS CELUI-CI
Abstract
(EN) A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.
(FR) L'invention porte sur un procédé pour le retrait sélectif d'un constituant d'une phase liquide et par la suite le renvoi du constituant vers une phase liquide. Un nouveau composé de formule (I) [SUP]-[[L]-[G]]a (I), dans laquelle L représente un groupe de liaison, G représente un groupe aryle portant un groupe partant LG choisi parmi Cl, Br, I, un groupe sulfonate tel qu'un groupe triflate, un groupe diazoïque, un groupe nitrile, un groupe ester et un groupe alcoxy et le substituant Q est choisi parmi H, NR2, OR, CO2R, F, Cl, NO2 et CN et SUP représente un support ayant une pluralité de groupes -[L]-[G] liés au support, est mis en contact avec la phase liquide pour lier le constituant au composé (I), ce qui forme de cette manière un constituant capturé qui est séparé de la phase liquide et peut être renvoyé vers la phase liquide. Le composé (I) est particulièrement utile pour lier des catalyseurs homogènes pour les enlever d'un milieu réactionnel et renvoyer sélectivement le catalyseur vers le milieu réactionnel dans une étape ultérieure. Le composé est particulièrement utile pour des réactions de couplage croisé, par exemple dans des réactions de Suzuki.
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