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1. (WO2014083109) PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS

Pub. No.:    WO/2014/083109    International Application No.:    PCT/EP2013/074974
Publication Date: Fri Jun 06 01:59:59 CEST 2014 International Filing Date: Fri Nov 29 00:59:59 CET 2013
IPC: B01J 31/06
B01J 31/16
B01J 31/24
C08G 77/385
C08G 77/388
C08G 77/392
C08G 77/395
C07B 37/04
C07B 43/00
Applicants: PHOSPHONICS LTD
MURRAY, Paul
Inventors: MURRAY, Paul
WILKES, Robin
NORTH, Christopher
Title: PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS
Abstract:
A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.