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1. (WO2014083109) PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2014/083109 International Application No.: PCT/EP2013/074974
Publication Date: 05.06.2014 International Filing Date: 28.11.2013
IPC:
B01J 31/06 (2006.01) ,B01J 31/16 (2006.01) ,B01J 31/24 (2006.01) ,C08G 77/385 (2006.01) ,C08G 77/388 (2006.01) ,C08G 77/392 (2006.01) ,C08G 77/395 (2006.01) ,C07B 37/04 (2006.01) ,C07B 43/00 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31
Catalysts comprising hydrides, coordination complexes or organic compounds
02
containing organic compounds or metal hydrides
06
containing polymers
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31
Catalysts comprising hydrides, coordination complexes or organic compounds
16
containing coordination complexes
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31
Catalysts comprising hydrides, coordination complexes or organic compounds
16
containing coordination complexes
24
Phosphines
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04
Polysiloxanes
38
Polysiloxanes modified by chemical after-treatment
382
containing atoms other than carbon, hydrogen, oxygen or silicon
385
containing halogens
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04
Polysiloxanes
38
Polysiloxanes modified by chemical after-treatment
382
containing atoms other than carbon, hydrogen, oxygen or silicon
388
containing nitrogen
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04
Polysiloxanes
38
Polysiloxanes modified by chemical after-treatment
382
containing atoms other than carbon, hydrogen, oxygen or silicon
392
containing sulfur
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
77
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
04
Polysiloxanes
38
Polysiloxanes modified by chemical after-treatment
382
containing atoms other than carbon, hydrogen, oxygen or silicon
395
containing phosphorus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
37
Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
04
Substitution
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
43
Formation or introduction of functional groups containing nitrogen
Applicants:
MURRAY, Paul [IE/GB]; GB
PHOSPHONICS LTD [GB/GB]; 114 Milton Park Oxford Oxfordshire OX14 4SA, GB
Inventors:
MURRAY, Paul; GB
WILKES, Robin; GB
NORTH, Christopher; GB
Agent:
GEARY, Stephen; 4 The Gatehouse 2 High Street Harpenden Hertfordshire AL5 2TH, GB
Priority Data:
1221402.928.11.2012GB
Title (EN) PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM AND ITS USE IN CROSS-COUPLING REACTIONS
(FR) PROCÉDÉ POUR LE RETRAIT D'UN CATALYSEUR D'UN MILIEU EN PHASE LIQUIDE ET SON RENVOI VERS CELUI-CI
Abstract:
(EN) A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.
(FR) L'invention porte sur un procédé pour le retrait sélectif d'un constituant d'une phase liquide et par la suite le renvoi du constituant vers une phase liquide. Un nouveau composé de formule (I) [SUP]-[[L]-[G]]a (I), dans laquelle L représente un groupe de liaison, G représente un groupe aryle portant un groupe partant LG choisi parmi Cl, Br, I, un groupe sulfonate tel qu'un groupe triflate, un groupe diazoïque, un groupe nitrile, un groupe ester et un groupe alcoxy et le substituant Q est choisi parmi H, NR2, OR, CO2R, F, Cl, NO2 et CN et SUP représente un support ayant une pluralité de groupes -[L]-[G] liés au support, est mis en contact avec la phase liquide pour lier le constituant au composé (I), ce qui forme de cette manière un constituant capturé qui est séparé de la phase liquide et peut être renvoyé vers la phase liquide. Le composé (I) est particulièrement utile pour lier des catalyseurs homogènes pour les enlever d'un milieu réactionnel et renvoyer sélectivement le catalyseur vers le milieu réactionnel dans une étape ultérieure. Le composé est particulièrement utile pour des réactions de couplage croisé, par exemple dans des réactions de Suzuki.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)