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1. WO2014082514 - METHOD FOR INITIATING STEM CELLS OF MAMMALS AND USE OF CHLORINE DIOXIDE IN PREPARATION OF DRUG FOR INITIATING STEM CELLS OF MAMMALS

Publication Number WO/2014/082514
Publication Date 05.06.2014
International Application No. PCT/CN2013/086018
International Filing Date 26.10.2013
IPC
A61K 33/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61P 17/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 25/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 25/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 33/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
20Elemental chlorine; Inorganic compounds releasing chlorine
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
Applicants
  • 刘学武 LIU, Xuewu [CN]/[CN]
Inventors
  • 刘学武 LIU, Xuewu
Priority Data
201210499300.X29.11.2012CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR INITIATING STEM CELLS OF MAMMALS AND USE OF CHLORINE DIOXIDE IN PREPARATION OF DRUG FOR INITIATING STEM CELLS OF MAMMALS
(FR) MÉTHODE D'INITIATION DE CELLULES SOUCHES DE MAMMIFÈRE ET UTILISATION DU DIOXYDE DE CHLORE DANS LA PRÉPARATION D'UN MÉDICAMENT POUR L'INITIATION DE CELLULES SOUCHES DE MAMMIFÈRE
(ZH) 一种启动哺乳动物干细胞的方法及二氧化氯在制备用于启动哺乳动物干细胞的药物的应用
Abstract
(EN) Provided in the present invention is a method for initiating the proliferation, migration and differentiation of stem cells in mammals, comprising the following steps: preparing a stem cell initiation agent containing chlorine dioxide and administering the stem cell initiation agent to target tissues of mammals, wherein an effective amount of chlorine dioxide is provided when administering the stem cell initiation agent to the target tissues of mammals. Also provided in the present invention is the use of chlorine dioxide in the preparation of a drug for initiating the proliferation, migration and differentiation of stem cells. The method of the present invention has a broad application range, and is suitable for various requirements of treating diseases using the tissue regeneration ability and immunity regulation ability of stem cells or prompting the initiation of the proliferation, migration and differentiation of stem cells in injured organs and organisms having regenerated tissues; furthermore, using the method of the present invention, the proliferation, migration and differentiation of stem cells can be initiated quickly and moderately; and the method has few side effects or no side effects, and can continuously be used for initiating the proliferation, migration and differentiation of stem cells.
(FR) L'invention concerne une méthode permettant de déclencher la prolifération, la migration et la différenciation de cellules souches chez un mammifère, ladite méthode consistant à : préparer un agent d'initiation des cellules souches contenant du dioxyde de chlore, et administrer l'agent à des tissus cibles chez un mammifère, la quantité de dioxyde de chlore efficace étant apportée lors de cette administration. L'invention concerne également l'utilisation du dioxyde de chlore dans la préparation d'un médicament permettant d'initier la prolifération, la migration et la différenciation de cellules souches. La méthode selon l'invention présente un large éventail d'applications, et répond à différentes exigences thérapeutiques utilisant la capacité de régénération tissulaire et la capacité de régulation immunitaire des cellules souches ou sollicitant l'initiation de la prolifération, de la migration et de la différenciation des cellules souches dans des organes lésés et des organismes ayant des tissus régénérés ; par ailleurs, la méthode de l'invention permet d'initier rapidement et modérément la prolifération, la migration et la différenciation des cellules souches ; et la méthode présente peu ou pas d'effets secondaires, et peut être utilisée en continu pour initier la prolifération, la migration et la différenciation des cellules souches.
(ZH) 本发明提供了一种启动哺乳动物体内干细胞增殖、迁移和分化的方法,该方法包括:制备含二氧化氯的干细胞启动剂以及对哺乳动物目标组织给予所述干细胞启动剂的步骤,其中所述干细胞启动剂被给予哺乳动物目标组织时提供有效量的二氧化氯。本发明还提供了二氧化氯在制备用于启动干细胞增殖、迁移和分化药物中的应用。本发明的方法适用范围广,适用于各种需要利用干细胞组织再生能力和免疫调节能力治疗疾病或促使损伤器官、组织再生的机体中干细胞的增殖、迁移和分化的启动;此外,采用本发明的方法能快速、且适度地启动干细胞的增殖、迁移和分化;本方法副作用很小或者无副作用,并能持续地发挥启动干细胞增殖、迁移和分化的作用。
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