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1. WO2014081718 - AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS

Publication Number WO/2014/081718
Publication Date 30.05.2014
International Application No. PCT/US2013/070788
International Filing Date 19.11.2013
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
C07D 471/04 (2006.01)
C07D 519/00 (2006.01)
CPC
A61K 31/506
A61K 31/5355
A61K 31/5377
A61K 31/538
A61K 31/541
A61K 45/06
Applicants
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US
Inventors
  • BRYAN, Marian C.; US
  • CHAN, Bryan; US
  • HANAN, Emily; US
  • HEFFRON, Timothy; US
  • PURKEY, Hans; US
  • ELLIOTT, Richard Leonard; GB
  • HEALD, Robert; GB
  • KNIGHT, Jamie; GB
  • LAINCHBURY, Michael; GB
  • SEWARD, Eileen M.; GB
Agents
  • PENG, Tony W.; Genentech, Inc. 1 DNA Way Mail Stop 49 South San Francisco, California 94080, US
Priority Data
61/728,48720.11.2012US
61/784,49414.03.2013US
61/866,16415.08.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS
(FR) COMPOSÉS AMINOPYRIMIDINES EN TANT QU'INHIBITEURS DE MUTANTS D'EGFR CONTENANT T790M
Abstract
(EN)
This invention relates to novel compounds of formula (I) which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer. (Formula I)
(FR)
Cette invention concerne de nouveaux composés de formule (I) qui sont des inhibiteurs de mutants d'EGFR contenant T790M, des compositions pharmaceutiques les contenant, des procédés pour leur préparation et leur utilisation en thérapie pour la prévention ou le traitement du cancer. (Formule I).
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