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1. WO2014081322 - SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES WITH ULTRA-THIN POLYMER LAYERS, THE METHOD OF THEIR PREPARATION AND APPLICATION

Publication Number WO/2014/081322
Publication Date 30.05.2014
International Application No. PCT/PL2013/050031
International Filing Date 19.11.2013
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
26
Iron; Compounds thereof
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
30
Nano-technology for materials or surface science, e.g. nano-composites
C CHEMISTRY; METALLURGY
01
INORGANIC CHEMISTRY
G
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F94
49
Compounds of iron
02
Oxides; Hydroxides
08
Ferroso-ferric oxide (Fe3O4)
A61K 49/18 (2006.01)
A61K 33/26 (2006.01)
B82Y 5/00 (2011.01)
B82Y 30/00 (2011.01)
C01G 49/08 (2006.01)
CPC
A61K 49/0093
A61K 49/1863
B82Y 15/00
B82Y 30/00
B82Y 5/00
C01G 49/02
Applicants
  • UNIWERSYTET JAGIELLONSKI; Kraków ul. Gołębia 24 PL-31-007 Kraków, PL
Inventors
  • ZAPOTOCZNY, Szczepan; PL
  • KANIA, Gabriela; PL
  • SZPAK, Agnieszka; PL
  • NOWAKOWSKA, Maria; PL
Agents
  • CZARNIK, Maciej; Kraków JCET, Jagiellonian University ul. Bobrzynskiego 14 PL-30-348 Kraków, PL
Priority Data
P.40170621.11.2012PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES WITH ULTRA-THIN POLYMER LAYERS, THE METHOD OF THEIR PREPARATION AND APPLICATION
(FR) NANOPARTICULES D'OXYDE DE FER SUPERPARAMAGNÉTIQUE COMPORTANT DES COUCHES POLYMÈRES ULTRAMINCES, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION
Abstract
(EN)
This invention relates to superparamagnetic iron oxide nanoparticles with ultra-thin polymer layers characterized in that they consist of superparamagnetic iron oxide cores co- precipitated with polycation, and a hydrophilic coating consisting of at least one ultra-thin layer of polyelectrolyte. The invention also provides a method for producing superparamagnetic nanoparticles according to the invention, and the use of superparamagnetic nanoparticles according to the invention as a contrast agent in magnetic resonance imaging and/or fluorescence imaging and/or fluorescence microscopy.
(FR)
La présente invention concerne des nanoparticules d'oxyde de fer superparamagnétique comportant des couches polymères ultraminces. Lesdites particules sont caractérisées en ce qu'elles sont constituées d'un cœur en oxyde de fer superparamagnétique co-précipité avec un polycation, et d'une enveloppe hydrophile constituée d'au moins une couche ultramince de polyélectrolyte. L'invention concerne également un procédé de production de nanoparticules superparamagnétiques selon l'invention et l'utilisation des nanoparticules superparamagnétiques selon l'invention en tant qu'agent de contraste dans l'imagerie par résonance magnétique et/ou l'imagerie par fluorescence et/ou la microscopie de fluorescence.
Also published as
Latest bibliographic data on file with the International Bureau