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4. (WO2014077866) REPLICATIVE MINICIRCLE VECTORS WITH IMPROVED EXPRESSION

Pub. No.:    WO/2014/077866    International Application No.:    PCT/US2013/000259
Publication Date: Fri May 23 01:59:59 CEST 2014 International Filing Date: Tue Nov 19 00:59:59 CET 2013
IPC: C12N 15/63
Applicants: NATURE TECHNOLOGY CORPORATION
Inventors: WILLIAMS, James, A.
Title: REPLICATIVE MINICIRCLE VECTORS WITH IMPROVED EXPRESSION
Abstract:
The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of said DNA molecules.