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1. (WO2014074922) CONCENTRATING A TARGET MOLECULE FOR SENSING BY A NANOPORE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/074922 International Application No.: PCT/US2013/069304
Publication Date: 15.05.2014 International Filing Date: 08.11.2013
IPC:
G01N 33/543 (2006.01) ,C12Q 1/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
STRATOS GENOMICS, INC. [US/US]; 2401 Elliott Avenue Fifth Floor Seattle, Washington 98121, US
Inventors:
KOKORIS, Mark, Stamatios; US
MCRUER, Robert, N.; US
Agent:
HARWOOD, Eric, A.; Seed Intellectual Property Law Group PLLC Suite 5400 701 Fifth Avenue Seattle, Washington 98104-7064, US
Priority Data:
61/724,82109.11.2012US
Title (EN) CONCENTRATING A TARGET MOLECULE FOR SENSING BY A NANOPORE
(FR) CONCENTRATION D'UNE MOLÉCULE VISÉE EN VUE D'UNE DÉTECTION PAR UN NANO-PORE
Abstract:
(EN) Methods and related products are disclosed that improve the probability of interaction between a target molecule and a nanopore by capturing the target molecule on a surface comprising the nanopore. The captured target molecule, the nanopore, or both, are able to move relative to each other along the surface. When the leader of the target molecule is in proximity with the nanopore, interaction of the target portion of the target molecule with the nanopore occurs, thereby permitting sensing of the target portion. Confining the target molecule and nanopore in this manner leads to significantly enhanced interaction with the nanopore.
(FR) L'invention concerne des procédés et des produits apparentés qui améliorent la probabilité d'interaction entre une molécule visée et un nano-pore en capturant la molécule visée sur une surface comportant le nano-pore. La molécule visée capturée et/ou le nano-pore sont susceptibles de se déplacer l'un par rapport à l'autre le long de la surface. Lorsque la partie de tête de la molécule visée se trouve à proximité du nano-pore, l'interaction de la partie visée de la molécule visée avec le nano-pore a lieu, permettant ainsi la détection de la partie visée. Le fait de confiner la molécule visée et le nano-pore de cette manière conduit à une interaction nettement renforcée avec le nano-pore.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2890515EP2917732