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1. WO2014071363 - TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

Publication Number WO/2014/071363
Publication Date 08.05.2014
International Application No. PCT/US2013/068473
International Filing Date 05.11.2013
IPC
C07D 311/78 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
A61K 31/352 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 311/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
C07D 311/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • ZAFGEN, INC. [US]/[US]
Inventors
  • PALLIN, Thomas, David
  • CRAMP, Susan, Mary
  • ZAHLER, Robert
Agents
  • KAVANAUGH, Theresa, C.
Priority Data
61/722,45505.11.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
(FR) COMPOSÉS TRICYCLIQUES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
Abstract
(EN) The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
(FR) L'invention concerne des composés tricycliques et leur utilisation dans le traitement de troubles médicaux, tels que l'obésité. L'invention concerne des compositions pharmaceutiques et des procédés de fabrication de divers composés tricycliques. Les composés sont considérés comme ayant une activité contre la méthionyl aminopeptidase 2.
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