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1. WO2014069295 - METHOD FOR PRODUCING CHRONIC CYSTITIS MODEL NON-HUMAN ANIMAL

Publication Number WO/2014/069295
Publication Date 08.05.2014
International Application No. PCT/JP2013/078665
International Filing Date 23.10.2013
Chapter 2 Demand Filed 11.04.2014
IPC
A01K 67/027 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
G01N 33/15 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A01K 2207/20
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
20Animals treated with compounds which are neither proteins nor nucleic acids
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
G01N 33/5088
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5082Supracellular entities, e.g. tissue, organisms
5088of vertebrates
Applicants
  • 国立大学法人京都大学 KYOTO UNIVERSITY [JP]/[JP]
Inventors
  • 寳満 隆 HOMAN Takashi
  • 中川 貴之 NAKAGAWA Takayuki
  • 金子 周司 KANEKO Shuji
Agents
  • 辻丸 光一郎 TSUJIMARU Koichiro
Priority Data
2012-23852830.10.2012JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING CHRONIC CYSTITIS MODEL NON-HUMAN ANIMAL
(FR) PROCÉDÉ DE PRODUCTION D'ANIMAL NON HUMAIN MODÈLE À CYSTITE CHRONIQUE
(JA) 慢性膀胱炎モデル非ヒト動物の製造方法
Abstract
(EN)
Provided is a method for producing a chronic cystitis model non-human animal. According to the method for producing a chronic cystitis model non-human animal of the present invention, a model animal that can develop clinical conditions of chronic cystitis adequately can be provided by administering hydrogen peroxide to a non-human animal. For example, the above-mentioned hydrogen peroxide can be administered to the bladder directly or indirectly preferably through the urethra. The model non-human animal produced by the production method of the present invention can keep clinical conditions of cystitis for a long period, and therefore it is considered that the model non-human animal is extremely useful, for example, for the screening for a candidate therapeutic agent for chronic cystitis.
(FR)
L'invention concerne un procédé de production d'un animal non humain modèle à cystite chronique. Selon le procédé de production d'un d'animal non humain modèle à cystite chronique de la présente invention, un animal modèle qui peut développer des états cliniques de cystite chronique de façon appropriée peut être créé par administration de peroxyde d'hydrogène à un animal non humain. Par exemple, le peroxyde d'hydrogène susmentionné peut être administré directement ou indirectement à la vessie, de préférence à travers l'urètre. L'animal non humain modèle produit par le procédé de production de la présente invention peut maintenir des états cliniques de cystite pendant une longue période et, par conséquent, on considère que l'animal non humain modèle est extrêmement utile, par exemple, pour le dépistage d'un agent thérapeutique candidat d'une cystite chronique.
(JA)
 慢性膀胱炎モデル非ヒト動物の製造方法を提供する。 本発明の慢性膀胱炎モデル非ヒト動物の製造方法によれば、過酸化水素を非ヒト動物に投与することで、慢性膀胱炎の病態を適切に表すモデル動物を提供できる。前記過酸化水素は、例えば、直接的または間接的に膀胱に投与でき、尿道からの投与が好ましい。本発明の製造方法により得られたモデル非ヒト動物は、膀胱炎の病態を長く維持できるため、例えば、慢性膀胱炎の治療候補剤のスクリーニングに、極めて有用といえる。
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