Processing

Please wait...

Settings

Settings

Goto Application

1. WO2014066836 - PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME

Publication Number WO/2014/066836
Publication Date 01.05.2014
International Application No. PCT/US2013/066939
International Filing Date 25.10.2013
IPC
A61K 31/5025 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • USHER III INITIATIVE, INC. [US]/[US]
Inventors
  • BURLI, Roland Werner
  • ESMIEU, William Rameshchandra Krishna
  • LOCK, Christopher James
  • MALAGU, Karine Fabienne
  • OWENS, Andrew Pate
  • HARTE, William Edward
Agents
  • LANGER, Matthew E.
Priority Data
61/718,61125.10.2012US
61/775,40208.03.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
(FR) PYRAZOLOPYRIDAZINES ET MÉTHODES DE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES DE LA RÉTINE ET DE LA PERTE D'AUDITION ASSOCIÉE AU SYNDROME D'USHER
Abstract
(EN) Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein. Usher Syndrome, a rare genetic disorder and a leading cause of deafness and blindness, is associated with a mutation in any one of ten genes.
(FR) La présente invention concerne des composés, des compositions et des méthodes pour le traitement de maladies dégénératives de la rétine, telles que la rétinite pigmentaire, l'amaurose congénitale de Leber, des dégénérescences rétiniennes syndromiques, la dégénérescence maculaire liée à l'âge et le syndrome d'Usher, ainsi que la perte d'audition associée au syndrome d'Usher. Le syndrome d'Usher qui est une maladie génétique et une cause majeure de surdité et de cécité, est associé à une mutation dans un gène quelconque parmi dix gènes.
Latest bibliographic data on file with the International Bureau