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1. WO2014066835 - PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME

Publication Number WO/2014/066835
Publication Date 01.05.2014
International Application No. PCT/US2013/066938
International Filing Date 25.10.2013
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C07D 487/04 (2006.01)
CPC
C07D 487/04
Applicants
  • USHER III INITIATIVE, INC. [US/US]; 191 North Wacker Drive Suite 2090 Chicago, Illinois 60606, US
Inventors
  • BURLI, Roland Werner; GB
  • ESMIEU, William Rameshchandra Krishna; GB
  • LOCK, Christopher James; GB
  • MALAGU, Karine Fabienne; GB
  • OWENS, Andrew Pate; GB
  • HARTE, William Edward; US
Agents
  • LANGER, Matthew E.; Cooley LLP 1299 Pennsylvania Ave Suite 700 Washington, District of Columbia 20004, US
Priority Data
61/718,59325.10.2012US
61/775,37608.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
(FR) PYRAZOLOPYRIDAZINES ET MÉTHODES POUR TRAITER DES MALADIES DÉGÉNÉRATIVES DE LA RÉTINE ET LA PERTE D'AUDITION ASSOCIÉE AU SYNDROME DE USHER
Abstract
(EN)
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
(FR)
La présente invention concerne des composés, des compositions et des méthodes pour le traitement des maladies dégénératives de la rétine telles que la rétinite pigmentaire, l'amaurose congénitale de Leber, les dégénérescences rétiniennes syndromiques, la dégénérescence maculaire liée à l'âge et le syndrome de Usher, et de la perte d'audition associée au syndrome de Usher.
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