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1. WO2014060581 - USE OF HYDROXYTIROSOL AND DERIVATIVES THEREOF AS QUORUM QUENCHERS

Publication Number WO/2014/060581
Publication Date 24.04.2014
International Application No. PCT/EP2013/071845
International Filing Date 18.10.2013
Chapter 2 Demand Filed 18.08.2014
IPC
A61K 31/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A01N 31/16
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
31Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
08Oxygen or sulfur directly attached to an aromatic ring system
16with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
A01N 37/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
02Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
A01N 37/38
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
36containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
38having at least one oxygen or sulfur atom attached to an aromatic ring system
A23L 3/3481
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
3Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
34by treatment with chemicals
3454in the form of liquids or solids
3463Organic compounds; Microorganisms; Enzymes
3481Organic compounds containing oxygen
A23L 3/3526
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
3Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
34by treatment with chemicals
3454in the form of liquids or solids
3463Organic compounds; Microorganisms; Enzymes
3526Organic compounds containing nitrogen
A23L 3/3535
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
3Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
34by treatment with chemicals
3454in the form of liquids or solids
3463Organic compounds; Microorganisms; Enzymes
3535Organic compounds containing sulfur
Applicants
  • SEPROX BIOTECH, S.L. [ES]/[ES]
Inventors
  • AUÑÓN CALLES, David
  • ALLENDE PRIETO, Ana
  • FÁBREGAS CASAL, Jaime
  • GÓMEZ-ACEBO GULLÓN, Eduardo
Agents
  • BERNARDO NORIEGA, Francisco
Priority Data
12382400.518.10.2012EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) USE OF HYDROXYTIROSOL AND DERIVATIVES THEREOF AS QUORUM QUENCHERS
(FR) UTILISATION DE L'HYDROXYTIROSOL ET DE SES DÉRIVÉS COMME DÉSACTIVATEURS DE QUORUM
Abstract
(EN) Herein is described the quorum quenching activity of compounds of formula (I) or (II) such as hydroxytyrosol (HT), hydroxytyrosol acetate (HTA), 3,4-dihydroxyphenylacetic acid (DOPAC) and derivatives thereof. It is also described their use in the treatment of bacterial infections or a disorder associated with biofilm formation in a subject, associated with quorum sensing caused by pathogenic bacteria as well as their use in the manufacturing of food, foodpakage, medical devices and pharmaceutical compositions.
(FR) L'invention concerne l'activité de désactivation de quorum des composés de formule (I) ou (II) tels que l'hydroxytyrosol (HT), l'acétate d'hydroxytyrosol (HTA), l'acide 3,4-dihydroxyphénylacétique (DOPAC) et leurs dérivés. L'invention concerne également leur utilisation dans le traitement d'infections bactériennes ou d'un trouble associé à la formation de biofilm chez un sujet, en association avec la détection de quorum provoquée par des bactéries pathogènes, ainsi que leur utilisation dans la transformation des aliments, la fabrication d'emballages de produits alimentaires, de dispositifs médicaux et de compositions pharmaceutiques.
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