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1. WO2014059021 - ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS

Publication Number WO/2014/059021
Publication Date 17.04.2014
International Application No. PCT/US2013/064136
International Filing Date 09.10.2013
IPC
A61K 49/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
CPC
A61K 49/1884
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1884Nanotubes, nanorods or nanowires
A61K 49/1896
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1896not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
C12N 2770/00031
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
00031Uses of virus other than therapeutic or vaccine, e.g. disinfectant
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • CASE WESTERN RESERVE UNIVERSITY [US]/[US]
Inventors
  • STEINMETZ, Nicole
Agents
  • RUSSELL, Raymond, N.
Priority Data
61/711,49209.10.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS
(FR) NANOPARTICULES DE VIRUS DE PLANTE EN FORME DE BÂTONNET EN TANT QUE PLATES-FORMES D'AGENT D'IMAGERIE
Abstract
(EN)
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
(FR)
La présente invention concerne un virus de plante en forme de bâtonnet ayant une surface intérieure et une surface extérieure, et au moins un agent d'imagerie qui est lié à la surface intérieure et / ou extérieure. Les virus en forme de bâtonnet peuvent être combinés en nanoparticules sphériques plus grandes. Un virus de plante en forme de bâtonnet ou des nanoparticules sphériques comprenant un agent d'imagerie peuvent être utilisés dans un procédé de génération d'une image d'une région de tissu d'un sujet, telle qu'une tumeur ou un tissu d'athérosclérotique par administration de la particule de virus au sujet et génération d'une image de la région de tissu du sujet à laquelle la particule virale a été distribuée.
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