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1. (WO2014044854) A METHOD FOR PROGNOSIS OF GLOBAL SURVIVAL AND SURVIVAL WITHOUT RELAPSE IN HEPATOCELLULAR CARCINOMA

Pub. No.:    WO/2014/044854    International Application No.:    PCT/EP2013/069753
Publication Date: Fri Mar 28 00:59:59 CET 2014 International Filing Date: Tue Sep 24 01:59:59 CEST 2013
IPC: C12Q 1/68
Applicants: INTEGRAGEN
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
UNIVERSITE PARIS DESCARTES
Inventors: DE REYNIES, Aurélien
LAURENT-PUIG, Pierre
ZUCMAN-ROSSI, Jessica
NAULT, Jean-Charles
Title: A METHOD FOR PROGNOSIS OF GLOBAL SURVIVAL AND SURVIVAL WITHOUT RELAPSE IN HEPATOCELLULAR CARCINOMA
Abstract:
The present invention relates to the technical field of hepatocellular carcinoma (HCC) management, and more precisely to the prognosis of HCC aggressiveness and associated therapeutic decisions. The invention provides a new prognosis method of HCC aggressiveness, based on determination in vitro and analysis of an expression profile comprising genes TAF9, RAMP3, HN1, KRT19, and RAN. The invention also provides kits for the prognosis of HCC aggressiveness, and methods of treatment of HCC in a subject based on a preliminary prognosis of said subject HCC aggressiveness.