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1. (WO2014044854) A METHOD FOR PROGNOSIS OF GLOBAL SURVIVAL AND SURVIVAL WITHOUT RELAPSE IN HEPATOCELLULAR CARCINOMA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/044854 International Application No.: PCT/EP2013/069753
Publication Date: 27.03.2014 International Filing Date: 23.09.2013
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
INTEGRAGEN [FR/FR]; Génopole Campus 1 5 rue Henri Desbruères Génavenir 8 F-91000 Evry, FR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, rue de Tolbiac F-75013 Paris, FR
UNIVERSITE PARIS DESCARTES [FR/FR]; 12, rue de l'Ecole de Médecine F-75006 Paris, FR
Inventors:
DE REYNIES, Aurélien; FR
LAURENT-PUIG, Pierre; FR
ZUCMAN-ROSSI, Jessica; FR
NAULT, Jean-Charles; FR
Agent:
REGIMBEAU; 20, rue de Chazelles F-75847 Paris Cedex 17, FR
Priority Data:
12306146.721.09.2012EP
61/704,36021.09.2012US
Title (EN) A METHOD FOR PROGNOSIS OF GLOBAL SURVIVAL AND SURVIVAL WITHOUT RELAPSE IN HEPATOCELLULAR CARCINOMA
(FR) PROCÉDÉ POUR PRONOSTIQUER UNE SURVIE GLOBALE ET UNE SURVIE SANS RECHUTE DANS UN CARCINOME HÉPATOCELLULAIRE
Abstract:
(EN) The present invention relates to the technical field of hepatocellular carcinoma (HCC) management, and more precisely to the prognosis of HCC aggressiveness and associated therapeutic decisions. The invention provides a new prognosis method of HCC aggressiveness, based on determination in vitro and analysis of an expression profile comprising genes TAF9, RAMP3, HN1, KRT19, and RAN. The invention also provides kits for the prognosis of HCC aggressiveness, and methods of treatment of HCC in a subject based on a preliminary prognosis of said subject HCC aggressiveness.
(FR) La présente invention est relative au domaine technique de la gestion d'un carcinome hépatocellulaire (HCC), et plus précisément au pronostic de l'agressivité d'un HCC et aux décisions thérapeutiques associées. L'invention divulgue un nouveau procédé de pronostic de l'agressivité d'un HCC, basé sur la détermination in vitro et l'analyse d'un profil d'expression comprenant les gènes TAF9, RAMP3, HN1, KRT19, et RAN. L'invention divulgue également des kits de pronostic de l'agressivité d'un HCC, ainsi que des procédés de traitement du HCC chez un sujet basés sur un pronostic préliminaire de l'agressivité du HCC chez ledit sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)