Processing

Please wait...

Settings

Settings

Goto Application

1. WO2014044853 - A NEW METHOD FOR CLASSIFICATION OF LIVER SAMPLES AND DIAGNOSIS OF FOCAL NODULE DYSPLASIA, HEPATOCELLULAR ADENOMA, AND HEPATOCELLULAR CARCINOMA

Publication Number WO/2014/044853
Publication Date 27.03.2014
International Application No. PCT/EP2013/069751
International Filing Date 23.09.2013
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/112
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
112Disease subtyping, staging or classification
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • INTEGRAGEN [FR]/[FR]
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR]/[FR]
  • UNIVERSITE PARIS DESCARTES [FR]/[FR]
Inventors
  • DE REYNIES, Aurélien
  • LAURENT-PUIG, Pierre
  • ZUCMAN-ROSSI, Jessica
  • NAULT, Jean-Charles
Agents
  • FAIVRE PETIT, Frédérique
Priority Data
12306145.921.09.2012EP
61/704,38321.09.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A NEW METHOD FOR CLASSIFICATION OF LIVER SAMPLES AND DIAGNOSIS OF FOCAL NODULE DYSPLASIA, HEPATOCELLULAR ADENOMA, AND HEPATOCELLULAR CARCINOMA
(FR) NOUVEAU PROCÉDÉ DE CLASSIFICATION D'ÉCHANTILLONS DE FOIE ET DIAGNOSTIC DE DYSPLASIE NODULAIRE FOCALE, D'ADÉNOME HÉPATOCELLULAIRE ET DE CARCINOME HÉPATOCELLULAIRE
Abstract
(EN)
The present invention relates to the technical field of liver diseases, their classification and diagnosis. It provides a new method for classifying a liver sample between non- hepatocellular sample; hepatocellular carcinoma (HCC) sample with further classification into one of subgroups G1 to G6; focal nodule dysplasia (FNH) sample; hepatocellular adenoma (HCA) sample with further classification into HNF1A mutated HCA, inflammatory HCA, β catenin mutated HCA or other HCA sample; and other benign liver sample, based on determination in vitro of genes expression profiles and analysis of the expression profile using algorithms calibrated with reference samples. The invention also provides kits for the classification of liver samples, and methods of treatment of liver disease in a subject based on a preliminary classification of a liver sample of said subject.
(FR)
La présente invention est relative au domaine technique des maladies du foie, à leur classification et à leur diagnostic. L'invention divulgue un nouveau procédé pour classifier un échantillon de foie entre un échantillon non-hépatocellulaire; un échantillon de carcinome hépatocellulaire (HCC) avec une classification supplémentaire dans un des sous-groupes G1 à G6; un échantillon de dysplasie nodulaire focale (FNH); un échantillon d'adénome hépatocellulaire (HCA) avec une classification supplémentaire en HCA muté en HNF1A, HCA inflammatoire, HCA muté en β caténine ou un autre échantillon de HCA; et un autre échantillon de foie bénin, sur la base de la détermination in vitro de profils d'expressions génétiques et d'analyse du profil d'expression en utilisant des algorithmes calibrés avec des échantillons de référence. L'invention divulgue également des kits pour la classification d'échantillons de foie, ainsi que des procédés de traitement de maladie du foie chez un sujet sur la base d'une classification préliminaire d'un échantillon de foie dudit sujet.
Latest bibliographic data on file with the International Bureau