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1. WO2014040070 - QUANTIFICATION OF LOCAL CIRCULATION WITH OCT ANGIOGRAPHY

Publication Number WO/2014/040070
Publication Date 13.03.2014
International Application No. PCT/US2013/059047
International Filing Date 10.09.2013
IPC
A61B 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
G01B 9/02 2006.1
GPHYSICS
01MEASURING; TESTING
BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
9Instruments as specified in the subgroups and characterised by the use of optical measuring means
02Interferometers
CPC
A61B 2576/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
2576Medical imaging apparatus involving image processing or analysis
02specially adapted for a particular organ or body part
A61B 3/0025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
0016Operational features thereof
0025characterised by electronic signal processing, e.g. eye models
A61B 3/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
102for optical coherence tomography [OCT]
A61B 3/1241
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
12for looking at the eye fundus, e.g. ophthalmoscopes
1241specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
A61B 5/0066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0062Arrangements for scanning
0066Optical coherence imaging
A61B 5/02007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02007Evaluating blood vessel condition, e.g. elasticity, compliance
Applicants
  • OREGON HEALTH & SCIENCE UNIVERSITY [US]/[US]
Inventors
  • HUANG, David
  • JIA, Yali
  • TOKAYER, Jason
  • TAN, Ou
Agents
  • KRESNAK, Mark, T.
Priority Data
61/699,25710.09.2012US
61/799,50215.03.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) QUANTIFICATION OF LOCAL CIRCULATION WITH OCT ANGIOGRAPHY
(FR) QUANTIFICATION DE CIRCULATION LOCALE AVEC ANGIOGRAPHIE OCT
Abstract
(EN) Impaired intraocular blood flow within vascular beds in the human eye are associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in one or more of the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions including, for example, the ocular disc, the temporal ellipse, the peripapillary retina, the peripapillary choroid, the macular retina, the macular choroid, the fovea avascular zone, and the area of non-perfusion. As described herein, a method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.
(FR) Une circulation sanguine intraoculaire altérée dans les lits vasculaires dans l'œil humain est associée à certaines maladies oculaires comprenant, par exemple, le glaucome, la rétinopathie diabétique et la dégénérescence maculaire liée à l'âge. Un procédé fiable pour quantifier la circulation sanguine dans un ou plusieurs des différents lits vasculaires intraoculaires pourrait donner des informations sur la composante vasculaire de la physiopathologie des maladies oculaires. En utilisant la tomographie en cohérence optique (OCT) à très haute vitesse, un nouvel algorithme d'angiographie 3D appelé angiographie à décorrélation d'amplitude à spectre fractionné (Split-Spectrum Amplitude-Decorrelation Angiography : SSADA) a été développé pour l'imagerie de la microcirculation dans différentes régions intraoculaires comprenant, par exemple, le disque oculaire, l'ellipse temporale, la rétine péripapillaire, la choroïde péripapillaire, la rétine maculaire, la choroïde maculaire, la zone avasculaire de la fovéa, et la zone de non-perfusion. Comme décrit présentement, un procédé pour quantifier les résultats de SSADA a été développé et utilisé pour détecter les changements de perfusion dans une maladie oculaire au stade précoce. Des modes de réalisation associés concernant des procédés pour mesurer quantitativement la circulation sanguine à différents sites de vascularisation intraoculaire, des systèmes pour mettre en pratique de tels procédés, et l'utilisation de ces procédés et systèmes pour diagnostiquer certaines maladies oculaires sont présentement décrits.
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