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1. (WO2014018932) EFFLUX INHIBITOR COMPOSITIONS AND METHODS OF TREATMENT USING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/018932 International Application No.: PCT/US2013/052402
Publication Date: 30.01.2014 International Filing Date: 26.07.2013
IPC:
A61K 9/14 (2006.01) ,A61K 31/473 (2006.01) ,A61K 9/51 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
Applicants:
BUNT, Antonius, Martinus Gustave [US/US]; NL
Inventors:
BUNT, Antonius, Martinus Gustave; NL
VAN TELLINGEN, Olaf; NL
Agent:
WILKINS, Andrew, T.; Lathrop & Gage LLP 28 State Street Boston, MA 02109, US
Priority Data:
61/676,68927.07.2012US
Title (EN) EFFLUX INHIBITOR COMPOSITIONS AND METHODS OF TREATMENT USING THE SAME
(FR) COMPOSITIONS INHIBITRICES D'ÉCOULEMENT ET MÉTHODES DE TRAITEMENT À L'AIDE DE CELLES-CI
Abstract:
(EN) The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., Breast Cancer Resistance Protein (BCRP) and P-Glycoprotein (P-GP)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and/or stem cells).
(FR) La présente invention concerne des compositions inhibitrices d'écoulement et des méthodes d'utilisation de ces agents pour le traitement d'états où l'activité de protéines transporteur d'écoulement (par exemple la protéine de résistance au cancer du sein (BCRP) et P-glycoprotéine (P-GP)) inhibent l'administration efficace d'un agent thérapeutique à un tissu cible (par exemple le cerveau, la moelle épinière, les nerfs, le liquide céphalorachidien, les testicules, les globes oculaires, les rétines, l'oreille interne, le placenta, la glande mammaire, le foie, le tractus biliaire, le rein, les intestins, le poumon, la corticosurrénale, l'endomètre, les cellules hématopoïétiques et/ou les cellules souches).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2880236EP2877159CN104736144JP2015523400AU2013295549BR112015001838
IN408/MUMNP/2015ES2656091