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35. (WO2014016314) FUSED QUINONIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/016314    International Application No.:    PCT/EP2013/065552
Publication Date: 30.01.2014 International Filing Date: 23.07.2013
Chapter 2 Demand Filed:    14.01.2014    
IPC:
C07D 221/18 (2006.01), C07D 231/12 (2006.01), C07D 231/56 (2006.01), C07D 239/26 (2006.01), C07D 239/72 (2006.01), C07D 311/82 (2006.01), C07D 333/10 (2006.01), A61K 31/473 (2006.01), A61K 31/517 (2006.01), A61K 31/352 (2006.01), A61K 31/381 (2006.01), A61K 31/4433 (2006.01), A61K 31/506 (2006.01), A61K 31/416 (2006.01), A61K 31/4155 (2006.01)
Applicants: CENTRO ATLANTICO DEL MEDICAMENTO S.A (CEAMED, S.A) [ES/ES]; Avda. Trinidad 61, 7ª Planta Torre Prof. Agustín Arévalo San Cristóbal de La Laguna E-38204 Santa Cruz de Tenerife (ES)
Inventors: McNAUGHTON SMITH, Grant; (ES).
ESTÉVEZ BRAUN, Ana; (ES).
JIMÉNEZ ALONSO, Sandra; (ES).
GUTIÉRREZ RAVELO, Ángel Domingo; (ES).
FERNÁNDEZ PÉREZ, Leandro; (ES).
DÍAZ CHICO, Bonifacio Nicolás; (ES)
Agent: ILLESCAS TABOADA, Manuel; Manuel Illescas y Asociados, S.L. (MIA) Principe de Vergara 197, Oficina 1°A E-28002 Madrid (ES)
Priority Data:
12177591.0 24.07.2012 EP
61/675,073 24.07.2012 US
Title (EN) FUSED QUINONIC COMPOUNDS
(FR) COMPOSÉS QUINONIQUES FUSIONNÉS
Abstract: front page image
(EN)A compound having the formula (I), for use in treating a disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transduction and Activators of Transcription (JAK-STAT) pathway. The activation of a JAK and/or STAT pathways are associated with several disease states such as immunological and inflammatory diseases, hyperproliferative disorders including cancer, and myeloproliferative diseases.
(FR)Cette invention concerne un composé de formule (I) utilisé dans le traitement d'une maladie ; une composition comprenant ledit composé quinonique fusionné de formule (I) et au moins un excipient pharmaceutiquement acceptable ; ainsi qu'une méthode permettant de moduler la voie d'activation des tyrosine kinases JAK (Janus kinases) et des facteurs de transcription STAT (signal transducer and activator of transcription). L'activation de la voie JAK et/ou STAT est associée à plusieurs maladies comme les maladies immunologiques et inflammatoires, les maladies hyperprolifératives, notamment le cancer, et les maladies myéloprolifératives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)