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1. (WO2014014951) 5-HT3 RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/014951 International Application No.: PCT/US2013/050746
Publication Date: 23.01.2014 International Filing Date: 16.07.2013
Chapter 2 Demand Filed: 29.04.2014
IPC:
C07D 401/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,C07D 451/12 (2006.01) ,C07D 471/02 (2006.01) ,C07D 487/14 (2006.01) ,C07D 498/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04
with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring system
06
Oxygen atoms
12
acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
08
Bridged systems
Applicants:
TAKEDA PHARMACEUTICAL COMPANY LIMITED [US/US]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi Osaka, 541-0045, US
HITCHCOCK, Stephen [US/US]; US (US)
MONENSCHEIN, Holger [DE/US]; US (US)
REICHARD, Holly [US/US]; US (US)
SUN, Huikai [CN/US]; US (US)
KIKUCHI, Shota [JP/US]; US (US)
MACKLIN, Todd [CA/US]; US (US)
HOPKINS, Maria [US/US]; US (US)
Inventors:
HITCHCOCK, Stephen; US
MONENSCHEIN, Holger; US
REICHARD, Holly; US
SUN, Huikai; US
KIKUCHI, Shota; US
MACKLIN, Todd; US
HOPKINS, Maria; US
Agent:
STEMERICK, David M.; 10410 Science Center Drive San Diego, California 92121, US
DUNCAN, Garreth, Andrew; D Young & Co 120 Holborn London EC1N 2DY, GB
Priority Data:
61/672,70917.07.2012US
61/708,52101.10.2012US
Title (EN) 5-HT3 RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DU RÉCEPTEUR 5-HT3
Abstract:
(EN) The present invention provides 5-HT3 receptor antagonists of Formula (I): which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
(FR) La présente invention concerne des antagonistes du récepteur 5-HT3 de formule (I) qui sont utiles pour le traitement de maladies pouvant être traitées par l'inhibition du récepteur 5-HT3, tels que le vomissement, la douleur, la pharmacodépendance, les troubles neurodégénératifs et psychiatriques, et les troubles gastro-intestinaux. La présente invention concerne en outre des compositions pharmaceutiques contenant de tels composés et des procédés pour préparer de tels composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2879115IL236702DOP2015000009EP2875011EA201590228SG11201500302U
CN104768943JP2015522618NZ704814AU2013290375BR112015001028ID2016/04647
MYPI 2015000110PH1/2015/500085VN42301IN957/DELNP/2015ES2659758EP3312169
TH180869TN2015000018