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1. (WO2014012614) FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2014/012614 International Application No.: PCT/EP2013/001774
Publication Date: 23.01.2014 International Filing Date: 14.06.2013
IPC:
C07D 471/04 (2006.01) ,C07D 487/04 (2006.01) ,C07D 498/04 (2006.01) ,A61K 31/4192 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4192
1,2,3-Triazoles
Applicants:
ARES TRADING S.A. [CH/CH]; Zone Industrielle de I'Ouriettaz CH-1170 Aubonne, CH
Inventors:
WHITTAKER, Ben; GB
STEELE, Chris; GB
HARDICK, David; GB
MITCHELL, Dale; GB
POMEL, Vincent; FR
QUATTROPANI, Anna; CH
BEHER, Dirk; CH
Agent:
MERCK KGAA; Dr. Lang PS - Patents & Scientific Information Frankfurter Strasse 250 64293 Darmstade, DE
Priority Data:
12176726.317.07.2012EP
61/672,43617.07.2012US
Title (EN) FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
(FR) DÉRIVÉS DE TRIAZOLE FUSIONNÉS EN TANT QUE MODULATEURS DE GAMMA SÉCRÉTASE
Abstract:
(EN) The present invention provides fused bicyclic triazole derivatives of Formula (I) useful as gamma secretase modulators (GSM), for the treatment of Alzheimer's disease and related diseases.
(FR) La présente invention concerne des dérivés de triazole bicycliques fusionnés de Formule (I) utiles en tant que modulateurs de gamma sécrétase (GSM), pour le traitement de la maladie d'Alzheimer et de maladies associées.
 front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)