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1. WO2013184602 - MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS

Publication Number WO/2013/184602
Publication Date 12.12.2013
International Application No. PCT/US2013/043954
International Filing Date 03.06.2013
IPC
C12P 7/52 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group
52Propionic acid; Butyric acids
C12N 1/20 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
C12N 1/21 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
21modified by introduction of foreign genetic material
CPC
C07C 31/207
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
31Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
18Polyhydroxylic acyclic alcohols
20Dihydroxylic alcohols
2071,4-Butanediol; 1,3-Butanediol; 1,2-Butanediol; 2,3-Butanediol
C07C 59/01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
C08G 18/284
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
18Polymeric products of isocyanates or isothiocyanates
06with compounds having active hydrogen
28characterised by the compounds used containing active hydrogen
2805Compounds having only one group containing active hydrogen
2815Monohydroxy compounds
284Compounds containing ester groups, e.g. oxyalkylated monocarboxylic acids
C08G 18/3206
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
18Polymeric products of isocyanates or isothiocyanates
06with compounds having active hydrogen
28characterised by the compounds used containing active hydrogen
30Low-molecular-weight compounds
32Polyhydroxy compounds; Polyamines; Hydroxyamines
3203Polyhydroxy compounds
3206aliphatic
C08G 63/06
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
06derived from hydroxycarboxylic acids
C08G 63/16
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
12derived from polycarboxylic acids and polyhydroxy compounds
16Dicarboxylic acids and dihydroxy compounds
Applicants
  • GENOMATICA, INC. [US]/[US]
Inventors
  • PHARKYA, Priti
  • BURGARD, Anthony, P.
  • VAN DIEN, Stephen, J.
  • OSTERHOUT, Robin, E.
  • TRAWICK, John, D.
  • KUCHINSKAS, Michael, P.
  • STEER, Brian
  • BURK, Mark, J.
Agents
  • GAY, David, A.
Priority Data
61/655,42904.06.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS
(FR) MICROORGANISMES ET PROCÉDÉS DE PRODUCTION DU 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL ET COMPOSÉS ASSOCIÉS
Abstract
(EN) The invention provides non-naturally occurring microbial organisms having a 4- hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4- hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4- hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
(FR) L'invention concerne des organismes microbiens d'origine non naturelle qui présentent une voie de production de 4-hydroxybutyrate, 1,4-butanediol ou d'un autre produit et qui sont aptes à produire du 4-hydroxybutyrate, 1,4-butanediol, ou un autre produit, l'organisme microbien comportant une ou plusieurs modifications génétiques. L'invention concerne également des procédés de production de 4-hydroxybutyrate, 1,4-butanediol ou d'un autre produit ou de produits associés à l'aide des organismes microbiens.
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