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1. (WO2013179264) COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/179264 International Application No.: PCT/IB2013/054486
Publication Date: 05.12.2013 International Filing Date: 31.05.2013
IPC:
A61K 38/17 (2006.01) ,A61K 31/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/18 (2006.01) ,A61P 25/22 (2006.01) ,A61P 25/24 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
UNIVERSIDAD ANDRES BELLO [CL/CL]; Avenida República Nº252 Santiago 8370134, CL
UNIVERSITEIT GENT [BE/BE]; Sint-Pietersnieuwstraat 25 B-9000 Gent, BE
KATHOLIEKE UNIVERSITEIT LEUVEN, KU LEUVEN R&D [BE/BE]; Katholieke Universiteit Leuven-KU Leuven R&D Waaistraat 6 Box 5105 B-3000 Leuven - Vlaams-Brabant, BE
Inventors:
STEHBERG LIBERMAN, Jimmy; CL
LEYBAERT SINIA, Luc Gilbert; BE
BULTYNCK DEMETS, Geert Albert; BE
RETAMAL LUCERO, Mauricio Antonio; CL
GONZALEZ NILO, Fernando Danilo; CL
Agent:
SARGENT & KRAHN; Av. Andres Bello 2711 Piso 19 Las Condes Santiago, CL
Priority Data:
61/653,14830.05.2012US
Title (EN) COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS
(FR) UTILISATION DE COMPOSÉS QUI MODULENT SÉLECTIVEMENT LA LIBÉRATION ASTROCYTAIRE DE SUBSTANCES PAR LES HÉMICANAUX DE CONNEXINE ET DE PANNEXINE, SANS INFLUENCER LES JONCTIONS COMMUNICANTES, POUR LE TRAITEMENT DES TROUBLES PSYCHIATRIQUES
Abstract:
(EN) The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also provided. Examples are shown for connexin 43, connexin 30 and pannexin 1 hemichannel modulators shown not to affect gap junctions, which were tested in different models for psychiatric disorders, comprising PTSD, memory, anxiety and depression.
(FR) Cette invention concerne l'utilisation de composés ou de leurs sels pharmaceutiquement acceptables qui modulent la libération astrocytaire de substances par les hémicanaux de connexine et de pannexine, pour le traitement des troubles psychiatriques. Les composés ou les sels pharmaceutiquement acceptables utilisés dans la présente invention comprennent les composés modulant, bloquant, ouvrant, inhibant et/ou activant de manière différentielle les hémicanaux de connexine et de pannexine par les astrocytes tout en n'affectant pas les jonctions communicantes. L'invention concerne également une méthode permettant de traiter les troubles psychiatriques et consistant à administrer au mammifère ou à l'homme une quantité thérapeutiquement efficace d'un composé ou d'un sel pharmaceutiquement acceptable qui module la libération astrocytaire de substances par les hémicanaux de connexine et de pannexine. L'invention concerne également des compositions pharmaceutiques et une méthode de criblage. Les modulateurs des hémicanaux de la connexine 43, la connexine 30 et la pannexine 1 s'avèrent ne pas influer sur les jonctions communicantes, sous la forme de composés non peptidiques et de peptides qui sont analysés dans différent modèles pour les troubles psychiatriques, notamment l'état de stress post-traumatique (ESPT), les troubles de la mémoire, l'anxiété et la dépression.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)