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1. WO2013177559 - HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS

Publication Number WO/2013/177559
Publication Date 28.11.2013
International Application No. PCT/US2013/042732
International Filing Date 24.05.2013
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
A61K 31/5377 (2006.01)
C07D 471/02 (2006.01)
CPC
A61K 31/4725
A61K 31/497
A61K 31/506
A61K 31/5377
A61K 31/5383
C07D 471/02
Applicants
  • CORCEPT THERAPEUTICS, INC. [US/US]; 149 Commonwealth Drive Menlo Park, CA 94025, US
Inventors
  • HUNT, Hazel; GB
  • JOHNSON, Tony; GB
  • RAY, Nicholas; GB
  • WALTERS, Iain; GB
Agents
  • TRIMBLE, Alexander, R.; Kilpatrick Townsend & Stockton, LLP Two Embarcadero Center, Eighth Floor San Francisco, CA 94111, US
Priority Data
61/651,66925.05.2012US
61/691,08320.08.2012US
61/715,90719.10.2012US
61/759,52001.02.2013US
61/781,62914.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
(FR) MODULATEURS DES RÉCEPTEURS DE GLUCOCORTICOÏDES CONSISTANT EN AZADÉCALINES À HÉTÉROARYLE CÉTONE FUSIONNÉ
Abstract
(EN)
The present Invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. In some embodiments, the present invention provides a pharmaceutical cmnposition including a pharmaceutically acceptable excipient and the compound of formula I. In some embodiments, the present invention provides a method of modulating a glucocorticoid receptor, the method including contacting a glucocorticoid receptor with a compound of formula I, thereby modulating the glucocorticoid receptor, as well as a method of treating a disorder through modulating a glucocorticoid receptor, the method including administering to a subject in need of such treatment, a therapeutically eftective amount of a compound of formula (I), thereby treating the disorder.
(FR)
La présente invention concerne des composés azadécalines à hétéroaryle cétone fusionné et des procédés d'utilisation des composés comme modulateurs des récepteurs de glucocorticoïdes.
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