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1. (WO2013177397) MULTIVALENT MENINGOCOCCAL CONJUGATES AND METHODS FOR PREPARING COJUGATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/177397 International Application No.: PCT/US2013/042428
Publication Date: 28.11.2013 International Filing Date: 23.05.2013
IPC:
A61K 47/48 (2006.01) ,A61K 39/095 (2006.01) ,A61P 37/04 (2006.01) ,A61P 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
095
Neisseria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES [US/US]; National Institutes Of Health Office Of Technology Transfer 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20852-7660, US
GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY [US/US]; U.S. Army Medical Research and Material Command 504 Scott Street Fort Detrick, MD 21702-5012, US
Inventors:
LEE, Che-Hung, Robert; US
PINTO, Valerian, B.; US
Agent:
GRAF, Susan, W.; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204, US
Priority Data:
61/651,38224.05.2012US
Title (EN) MULTIVALENT MENINGOCOCCAL CONJUGATES AND METHODS FOR PREPARING COJUGATES
(FR) CONJUGUÉS MÉNINGOCOCCIQUES MULTIVALENTS ET MÉTHODES DE PRÉPARATION ASSOCIÉES
Abstract:
(EN) Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4°C.
(FR) Cette invention concerne des conjugués méningococciques immunogènes capables d'induire des réponses immunitaires dirigées contre les polysaccharides méningococciques (PS) des sérogroupes A, C et W-135, et la protéine de liaison du facteur H (fHbp) des sérogroupes Y et B. Les conjugués décrits présentent également une activité bactéricide contre les sérogroupes A, C, W-135, Y, B et X du méningocoque. L'invention concerne également des méthodes améliorées permettant de préparer des conjugués, notamment des conjugués immunogènes, consistant à activer un polysaccharide avec un agent de cyanylation à environ 4 °C.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20150110829CN104428008IN9791/DELNP/2014