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1. (WO2013177195) 3',5'-CYCLIC PHOSPHATE PRODRUGS FOR HCV INFECTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/177195 International Application No.: PCT/US2013/042069
Publication Date: 28.11.2013 International Filing Date: 21.05.2013
IPC:
C07H 19/213 (2006.01) ,A61K 31/7076 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
213
containing cyclic phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
IDENIX PHARMACEUTICALS, INC. [US/US]; 320 Bent Street, Floor 4 Cambridge, Massachusetts 02141, US
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; 3 Rue Michel-Ange F-75794 Paris Cedex 16, FR
UNIVERSITÉ MONTPELLIER 2 SCIENCES ET TECHNIQUES; 2 Place Eugène Bataillon F-34095 Montpellier Cedex 5, FR
Inventors:
PARSY, Christophe Claude; FR
ALEXANDRE, Francois-Rene; FR
DOUSSON, Cyril B.; FR
DUKHAN, David; FR
GOSSELIN, Gilles; FR
RAHALI, Houcine; FR
SURLERAUX, Dominique; BE
Agent:
PATHAK, Rahul; Squire Sanders (US) LLP 275 Battery Street, Suite 2600 San Francisco, California 94111, US
Priority Data:
61/650,41522.05.2012US
61/695,22130.08.2012US
Title (EN) 3',5'-CYCLIC PHOSPHATE PRODRUGS FOR HCV INFECTION
(FR) PROMÉDICAMENTS DE 3',5'-PHOSPHATE CYCLIQUE POUR TRAITER UNE INFECTION PAR LE VIRUS DE L'HÉPATITE C
Abstract:
(EN) Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
(FR) L'invention concerne des composés, des compositions et des méthodes pour traiter des infections par Flaviviridae, notamment les infections par le virus de l'hépatite C (VHC). Dans certains modes de réalisation, l'invention concerne des composés et des compositions de dérivés de nucléoside, qui peuvent être administrés soit seuls soit en combinaison avec d'autres agents antiviraux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2852605