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1. WO2013164321 - PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

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Publication Number WO/2013/164321
Publication Date 07.11.2013
International Application No. PCT/EP2013/058939
International Filing Date 30.04.2013
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
C07D 403/12 (2006.01)
C07D 413/14 (2006.01)
C07D 403/14 (2006.01)
C07D 407/14 (2006.01)
A61K 31/506 (2006.01)
A61P 25/16 (2006.01)
CPC
A61K 31/506
C07D 403/12
C07D 403/14
C07D 405/14
C07D 407/14
C07D 413/14
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • BAKER-GLENN, Charles; GB
  • BURDICK, Daniel Jon; US
  • CHAMBERS, Mark; GB
  • CHAN, Bryan K.; US
  • CHEN, Huifen; US
  • ESTRADA, Anthony; US
  • SWEENEY, Zachary Kevin; US
Agents
  • MUELLER-AFRAZ, Simona; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data
61/642,01903.05.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
(FR) DÉRIVÉS DE PYRAZOLE AMINOPYRIMIDINE EN TANT QUE MODULATEURS DE LRRK2
Abstract
(EN)
Pyrazole compounds that are modulators of LRRK2, methods of making the compounds, and methods for using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
(FR)
L'invention concerne des composés de pyrazole qui sont des modulateurs de LRRK2, des procédés de fabrication des composés, et des procédés d'utilisation des composés pour le traitement de maladies associées à un récepteur de LRRK2, telles que la maladie de Parkinson.
Also published as
BR112014026952
CA2870049
CN104271569
EP2844652
JP2015515966
KR1020150016532
MX363118
RU0002637947
RU2014147381
Latest bibliographic data on file with the International Bureau
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