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1. (WO2013163567) NOVEL ALPHA-HELICAL PEPTIDOMIMETIC INHIBITORS AND METHODS USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/163567 International Application No.: PCT/US2013/038448
Publication Date: 31.10.2013 International Filing Date: 26.04.2013
IPC:
C07K 14/81 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA[US/US]; Center For Technology Transfer 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283, US
Inventors: GREENBAUM, Doron, C.; US
Agent: SILVA, Domingos, J.; Riverside Law, LLP 300 Four Falls Corporate Center, Suite 710 300 Conshohocken State Road West Conshohocken, PA 19428, US
Priority Data:
61/639,55227.04.2012US
Title (EN) NOVEL ALPHA-HELICAL PEPTIDOMIMETIC INHIBITORS AND METHODS USING SAME
(FR) INHIBITEURS PEPTIDOMIMÉTIQUES EN HÉLICE ALPHA INÉDITS ET LEURS MÉTHODES D'UTILISATION
Abstract:
(EN) The present invention includes a novel class of highly specific protease inhibitors. In one embodiment, the inhibitors of the invention are a-helical in structure. In another embodiment, the present invention represents the first demonstration of a highly specific cysteine protease inhibitor. The invention includes a composition comprising a peptide, or a salt thereof, having at least one a-helix, wherein the peptide inhibits a protease. In one embodiment, the peptide comprises at least two cysteine residues, wherein the at least two cysteine residues occupy i,i+4 positions in the peptide and are covalently connected through a linker. In another embodiment, the linker comprises alpha, alpha' -meta-xylylene.
(FR) La présente invention concerne une classe inédite d'inhibiteurs hautement spécifiques des protéases. Selon un mode de réalisation, les inhibiteurs de l'invention présentent une structure en hélice alpha. Selon un autre mode de réalisation, la présente invention constitue le premier exemple d'un inhibiteur hautement spécifique des protéases à cystéine.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)