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1. (WO2013163430) SERPINC1 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/163430 International Application No.: PCT/US2013/038218
Publication Date: 31.10.2013 International Filing Date: 25.04.2013
IPC:
C07H 21/04 (2006.01) ,C12N 15/113 (2010.01)
Applicants: ALNYLAM PHARMACEUTICALS, INC.[US/US]; 300 Third Street 3rd Floor Cambridge, MA 02142, US
Inventors: AKINC, Akin; US
SEHGAL, Alfica; US
TOUDJARSKA, Ivanka; US
FOSTER, Donald; US
MILSTEIN, Stuart; US
BETTENCOURT, Brian; US
MAIER, Martin; US
CHARISSE, Klaus; US
KUCHIMANCHI, Satyanarayana; US
RAJEEV, Kallanthottathil, G.; US
MANOHARAN, Muthiah; US
Agent: ZACHARAKIS, Maria Laccotripe; McCarter & English, LLP 265 Franklin Street Boston, MA 02110, US
Priority Data:
13/837,12915.03.2013US
61/638,95226.04.2012US
61/669,24909.07.2012US
61/734,57307.12.2012US
Title (EN) SERPINC1 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS D'ARNI CIBLANT SERPINC1 ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN) The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.
(FR) L'invention concerne des compositions d'ARNi, par exemple d'acide ribonucléique double brin (ARNdb), ciblant le gène Serpinc1, et des méthodes d'utilisation de ces compositions d'ARNi, par exemple d'ARNdb, pour inhiber l'expression de Serpinc1, ainsi que des méthodes de traitement de sujets présentant un trouble de saignement, tel qu'une hémophilie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)