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1. (WO2013163427) ANTIBODIES TO TREAT HIV-1 INFECTION

Pub. No.:    WO/2013/163427    International Application No.:    PCT/US2013/038214
Publication Date: Fri Nov 01 00:59:59 CET 2013 International Filing Date: Fri Apr 26 01:59:59 CEST 2013
IPC: C07K 16/46
C07K 16/10
C07K 16/28
A61K 39/44
A61P 31/18
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
Inventors: NABEL, Gary, J.
YANG, Zhi-yong
PEGU, Amarendra
GUO, Xiaoti
WU, Lan
Title: ANTIBODIES TO TREAT HIV-1 INFECTION
Abstract:
Bispecific antibodies are disclosed that include a first antigen binding domain that specifically binds to an HIV-1 envelope protein (such as gp120 or gp41), and a second antigen binding domain that is T cell activating and HIV-1 -activating, such as an scFv that specifically binds to CD3. In some embodiments, the bispecific antibody includes a scFv that specifically binds to an HIV-1 envelope protein (such as gp120 or gp41) and a scFv that that is T cell activating and HIV-1 -activating, such as an scFv that specifically binds to CD3. In additional embodiments, the bispecific antibody includes a Fab that specifically binds to an HIV-1 envelope protein (such as gp120 or gp41) and a scFv that that is T cell activating and HIV-1 -activating, such as an scFv that specifically binds to CD3. Multispecific antibodies are also disclosed that include these bispecific antibodies. Methods of using these bispecific antibodies, multispecific antibodies and nucleic acids encoding these antibodies are also disclosed.