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1. (WO2013163394) NUCLEASE-MEDIATED TARGETING WITH LARGE TARGETING VECTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/163394 International Application No.: PCT/US2013/038165
Publication Date: 31.10.2013 International Filing Date: 25.04.2013
IPC:
C12N 15/85 (2006.01) ,C12N 15/90 (2006.01) ,C07K 14/715 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC.[US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591, US
Inventors: FRENDEWEY, David; US
AUERBACH, Wojtek; US
VALENZUELA, David, M.; US
YANCOPOULOS, George, D.; US
LAI, Ka-Man Venus; US
Agent: WILLIAMSON, Kelly, J.; Alston & Bird LLP Bank of America Plaza 101 South Tryon Street, Suite 4000 Charlotte, NC 28280-4000, US
Priority Data:
61/638,26725.04.2012US
Title (EN) NUCLEASE-MEDIATED TARGETING WITH LARGE TARGETING VECTORS
(FR) CIBLAGE MÉDIÉ PAR NUCLÉASE AVEC DE GRANDS VECTEURS DE CIBLAGE
Abstract: front page image
(EN) Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double-strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target genomic locus in prokaryotic or eukaryotic cells using engineered nucleases are also provided.
(FR) L'invention concerne des compositions et des procédés pour effectuer une ou plusieurs modifications génétiques ciblées à un locus génomique cible par l'utilisation d'une recombinaison homologue facilitée par une rupture de simple ou double brin à ou près du locus génomique cible. L'invention concerne également des compositions et des procédés pour favoriser le rendement d'une recombinaison homologue entre un LTVEC et un locus génomique cible dans des cellules procaryotes ou eucaryotes à l'aide de nucléases génétiquement modifiées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)