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1. (WO2013163344) 2.2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/163344    International Application No.:    PCT/US2013/038064
Publication Date: 31.10.2013 International Filing Date: 24.04.2013
IPC:
C07J 63/00 (2006.01), A61K 31/565 (2006.01), A61P 29/00 (2006.01)
Applicants: REATA PHARMACEUTICALS, INC. [US/US]; 2801 Gateway Drive, Suite 150 Irving, TX 75063-2648 (US)
Inventors: ANDERSON, Eric; (US).
DECKER, Andrea; (CH).
LIU, Xiaofeng; (US)
Agent: VOGES, Mark, H.; Parker Highlander PLLC 1120 S. Capital of Texas Highway Building One, Suite 200 Austin, TX 78746 (US)
Priority Data:
61/775,288 08.03.2013 US
61/687,669 27.04.2012 US
61/780,444 13.03.2013 US
Title (EN) 2.2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
(FR) DÉRIVÉS 2,2-DIFLUOROPROPIONAMIDE DE BARDOXOLONE MÉTHYLE, LEURS FORMES POLYMORPHES ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-1 1-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b- octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
(FR)La présente invention concerne de manière générale le composé : N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-1 1-cyano-2,2,6a,6b,9,9,12a-heptaméthyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b- octadécahydropicén-4a-yl)-2,2-difluoropropanamide, ses formes polymorphes, ses procédés de préparation et d'utilisation, ses compositions pharmaceutiques, ainsi que des kits et articles manufacturés associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)